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Toll-like receptor 8 monoclonal antibody (44C143)

 
ALX-804-376-C100 100 µg 392.00 USD
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Product Specification

Alternative Name:TLR8, CD288
 
Clone:44C143
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to aa 750-850 of the cytoplasmic portion of human TLR8 (Toll-like receptor 8).
 
UniProt ID:Q9NR97
 
Species reactivity:Human, Mouse
 
Applications:Flow Cytometry, IHC (PS), WB
 
Recommended Dilutions/Conditions:Flow Cytometry (intracellular, 0.5-5µg per 106 cells; cell surface: see Xu et al. (2006) for details)
Immunohistochemistry (paraffin sections: 5µg/ml)
Western Blot (1-3µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~120kDa by Western blot.
Flow Cytometry: Suitable for cell surface and intracellular FC.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120kDa.
 
Technical Info/Product Notes:Replacement for ADI-CSA-825
 
Toll-like receptor 8 monoclonal antibody (44C143) Western blot
Figure: Western blot analysis of TLR8 in cell lysates from 293 transfected with human TLR8 using ALX-804-376 at a dilution of 2µg/ml. "
Toll-like receptor 8 monoclonal antibody (44C143) Immunohistochemistry
Figure: Immunohistochemical analysis of TLR8 in paraffin-embedded formalin-fixed human brain tissue using an isotype control (top) or MAb to Toll-like Receptor 8 (44C143) (Prod. No. ALX-804-376)."
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Toll-like receptor 8 monoclonal antibody (44C143) Western blot Toll-like receptor 8 monoclonal antibody (44C143) Immunohistochemistry

Product Literature References

TlR expression profile of human gingival margin-derived stem progenitor cells: K. Fawzy-El-Sayed, et al.; Med. Oral Patol. Oral Cir. Bucal. 21, e30 (2016), Abstract; Full Text
High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production: S. Xu, et al.; Surgery 140, 170 (2006), Abstract;

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