TANK-binding kinase 1, mAb (108A429)



ALX-804-372-C100	100 µg	279.00 USD

TANK-binding Kinase 1 (TBK1) is a member of the IKK family. TANK (TRAF-associated NF-κB activator) interacts with TBK1 and activates NF-κB in a kinase-dependent manner.

Product Specification

Alternative Name:	TBK1, T2K, NF-κB-activating kinase, NAK

Concentration:	0.5mg/ml

Purity Detail:	Protein G-affinity purified.

Formulation:	Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.

Clone:	108A429

Isotype:	Mouse IgG1

Immunogen:	Synthetic peptide corresponding to aa 563-577 (YYQFKKDKAERRLAYC) of human TBK1 (TANK-binding kinase 1).

Specificity:	Recognizes human, mouse, rat, dog and bovine TBK1. Detects a band of ~80kDa by Western blot.

Application:	Western Blot (1-2µg/ml)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Figure 1: Western blot analysis of TBK1 using MAb to TANK-binding Kinase 1 (108A429) (Prod. No. ALX-804-372) at 2μg/ml dilution against 10μg/lane of lysate from 293 cells untransfected (lane 1) and transfected with human TBK1 cDNA (lane 2).

Figure 2: Western blot analysis of TBK in human Daudi cell lysate (A) and mouse RAW cell lysate (B) using MAb to TANK-binding Kinase 1 (108A429) (Prod. No. ALX-.804-372) at 2μg/ml.

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Product Literature References

Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells: P. Osterlund, et al.; J. Virol. 79, 9608 (2005), Abstract;

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I: R. Sumpter, Jr., et al.; J. Virol. 79, 2689 (2005), Abstract; Full Text

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway: K.A. Fitzgerald, et al.; Nat. Immunol. 4, 491 (2003), Abstract;

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase: J.L. Pomerantz & D. Baltimore; EMBO J. 18, 6694 (1999), Abstract; Full Text