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Dnmt1 monoclonal antibody (60B1220.1)

ALX-804-369-C100 100 µg 323.00 USD
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Product Specification

Alternative Name:DNA methyltransferase-1
Immunogen:Synthetic peptide corresponding to aa 637-650 of human Dnmt1 (DNA methyltransferase-1).
UniProt ID:P26358
Species reactivity:Human, Mouse
Applications:ICC, IHC (PS), IP, WB
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1-2µg/ml)
Western Blot (0.1-0.5µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Use/Stability:Stable for 6 months when stored at +4°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Technical Info/Product Notes:Replacement for ADI-KAM-TF040
Figure: Western blot analysis for Dnmt1 using ALX-804-369 at 2µg/ml dilution against 10µg of cell lysates of mouse ES cell.
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Figure 2: Immunohistochemistry of Dnmt1 using ALX-804-369 at 2µg/ml on formalin-fixed paraffin-embedded medullar kidney tissue sections.
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Product Literature References

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal: K. Ghoshal, et al.; Mol. Cell. Biol. 25, 4727 (2005), Abstract;
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection: T.S. Lin, et al.; Cancer Lett. 226, 77 (2005), Abstract;
Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development: I.Y. Park, et al.; J. Cell Biochem. 94, 585 (2005), Abstract;
Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma: B.I. Srivastava and M.D. Srivastava; Leuk. Res. 29, 771 (2005), Abstract;
Immunology of cutaneous vasculitis associated with both etanercept and infliximab: M.D. Srivastava, et al.; Scand. J. Immunol. 61, 329 (2005), Abstract;
Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells: H. Xin, et al.; J. Biol. Chem. 279, 9539 (2004), Abstract; Full Text
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells: H. Kawasaki and K. Taira; Nature 431, 211 (2004), Abstract;
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer: Y.W. Leu, et al.; Cancer Res. 64, 8184 (2004), Abstract;
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells: M. Suzuki, et al.; Cancer Res. 64, 3137 (2004), Abstract; Full Text
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns: J.M. Craig, et al.; Hum. Mol. Genet. 12, 3109 (2003), Abstract; Full Text
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma: F. Kimura, et al.; Int. J. Cancer 104, 568 (2003), Abstract;
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation: Y.W. Leu, et al.; Cancer Res. 63, 6110 (2003), Abstract;
Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter: Z. Zhang, et al.; Mech. Ageing Dev. 123, 1257 (2002), Abstract;
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2: R.A. Alcock, et al.; Oncogene 21, 7883 (2002), Abstract;
The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases: C.N. Tsai, et al.; PNAS 99, 10084 (2002), Abstract; Full Text
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription: R. Santoro, et al.; Nat. Genet. 32, 393 (2002), Abstract;
Lsh, a member of the SNF2 family, is required for genome-wide methylation: K. Dennis, et al.; Genes Dev. 15, 2940 (2001), Abstract; Full Text

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