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Caspase-2 monoclonal antibody (10C6)

 
ALX-804-355-C100 100 µg 378.00 USD
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Product Specification

Clone:10C6
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Recombinant human caspase-2 (p19 subunit).
 
UniProt ID:P42575
 
Species reactivity:Human, Mouse, Rat
Dog, Monkey
 
Specificity:Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.
 
Applications:ELISA, Flow Cytometry, ICC, IHC (FS)
 
Recommended Dilutions/Conditions:Flow Cytometry (1µg/ml)
Immunocytochemistry (10-20µg/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment: M. Lopez-Cruzan, et al.; Cell Death Discov. (2016), Application(s): Immunocytochemistry,
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006), Abstract; Full Text
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol. 164, 89 (2004), Abstract; Full Text
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O’Reilly, et al.; Cell Death Differ. 9, 832 (2002), Abstract; Full Text

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