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Bcl-w monoclonal antibody (13F9)

 
ALX-804-353-C100 100 µg 334.00 USD
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Product Specification

Alternative Name:BCL2L2
 
Clone:13F9
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Recombinant human Bcl-w.
 
UniProt ID:Q92843
 
Species reactivity:Human, Mouse, Rat
Dog, Monkey
 
Applications:IP, WB
 
Application Notes:Excellent for Immunoprecipitation.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
804-353-n
Figure: Immunoprecipitation/Western blot showing the detection of Bcl-w in human and mouse cell lines. Lysates from 107 cells were immunoprecipitated by clone 13F9 and the fractionated proteins were then blotted with the same antibody. Hsp-70 expression was used as an equal loading control, and 293T cells transiently transfected with a human bcl-w expression construct were used as a positive control.
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804-353-n

Product Literature References

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic: J. Kuroda, et al.; PNAS 103, 14907 (2006), Abstract; Full Text
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity: J. Wilson-Annan, et al.; J. Cell Biol. 162, 877 (2003), Abstract; Full Text
Tissue expression and subcellular localization of the pro-survival molecule Bcl-w: L.A. O'Reilly, et al.; Cell Death Differ. 8, 486 (2001), Abstract;
Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine: D.M. Pritchard, et al.; Oncogene 19, 3955 (2000), Abstract;

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