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TRAIL-R3 (human) monoclonal antibody (HS301)

ALX-804-344A-C100 100 µg 360.00 USD
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Product Specification

Alternative Name:TRAIL receptor 3, DcR1, Death Receptor 1, TRID, CD263, TNFRSF 10C, TNF-related apoptosis-inducing ligand receptor 3, Tumor necrosis factor receptor superfamily member 10C
Immunogen:Recombinant human TRAIL-R3.
UniProt ID:O14798
Gene/Protein Identifier:8794 (Entrez GeneID)
Species reactivity:Human
Crossreactivity:Does not cross-react with human TRAIL-R1, -R2 or -R4.
Applications:Flow Cytometry, ICC
Application Notes:For Western blot of whole cell lysate, use PAb to TRAIL-R3 (human) (from goat) (Prod. No. ALX-210-744).
Formulation:Liquid. In PBS containing 0.05% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Figure: Receptor specificity of  the monoclonal antibodies HS301 for TRAIL-R3 (Prod. No. ALX-804-344).
Method: CV1/EBNA cells were transfected either with the empty expression vector pCDNA3 (vector control) or pCDNA3 encoding  TRAIL-R1 to TRAIL-R4.  Two days after transfection 1 x 106 cells were stained with mAb HS301 against TRAIL-R3 (Prod. No. ALX- 804-344).
All primary antibodies were used at 10 µg/ml, followed by biotinylated goat anti-mouse IgG1 and streptavidin-PE. Transfection efficiency was about 50% in all individual transfections.
Note: HS301 also detects endogenous cell surface expressed TRAIL-R3 in FACS (unpublished data). In most cell types endogenous TRAIL-R3 appears to be mainly expressed intracellular, why cell permeabilization may be required to obtain a signal by FACS.
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Product Literature References

Decreased affinity of recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) D269H/E195R to osteoprotegerin (OPG) overcomes TRAIL resistance mediated by the bone microenvironment: M.C. Bosman, et al.; J. Biol. Chem. 289, 1071 (2014), Abstract; Full Text
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008), Abstract;
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window: R. Koschny, et al.; Hepatology 45, 649 (2007), Abstract;
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004), Abstract; Full Text
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004), Abstract;
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004), Abstract;
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003), Abstract;

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