Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

TRAIL-R3 (human) monoclonal antibody (HS301)

 
ALX-804-344A-C100 100 µg 360.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:TRAIL receptor 3, DcR1, Death Receptor 1, TRID, CD263, TNFRSF 10C, TNF-related apoptosis-inducing ligand receptor 3, Tumor necrosis factor receptor superfamily member 10C
 
Clone:HS301
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human TRAIL-R3.
 
UniProt ID:O14798
 
Gene/Protein Identifier:8794 (Entrez GeneID)
 
Species reactivity:Human
 
Crossreactivity:Does not cross-react with human TRAIL-R1, -R2 or -R4.
 
Applications:Flow Cytometry, ICC
 
Application Notes:For Western blot of whole cell lysate, use PAb to TRAIL-R3 (human) (from goat) (Prod. No. ALX-210-744).
 
Formulation:Liquid. In PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
804-344-n
Figure: Receptor specificity of  the monoclonal antibodies HS301 for TRAIL-R3 (Prod. No. ALX-804-344).
Method: CV1/EBNA cells were transfected either with the empty expression vector pCDNA3 (vector control) or pCDNA3 encoding  TRAIL-R1 to TRAIL-R4.  Two days after transfection 1 x 106 cells were stained with mAb HS301 against TRAIL-R3 (Prod. No. ALX- 804-344).
All primary antibodies were used at 10 µg/ml, followed by biotinylated goat anti-mouse IgG1 and streptavidin-PE. Transfection efficiency was about 50% in all individual transfections.
Note: HS301 also detects endogenous cell surface expressed TRAIL-R3 in FACS (unpublished data). In most cell types endogenous TRAIL-R3 appears to be mainly expressed intracellular, why cell permeabilization may be required to obtain a signal by FACS.
ALX-804-344 graph
Please mouse over
804-344-n ALX-804-344 graph

Product Literature References

Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008), Abstract;
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window: R. Koschny, et al.; Hepatology 45, 649 (2007), Abstract;
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004), Abstract; Full Text
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004), Abstract;
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004), Abstract;
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003), Abstract;

Related Products

TRAIL-R3 polyclonal antibody 

ICC, WB | Print as PDF
 
ADI-905-216-100 100 µg 366.00 USD
Do you need bulk/larger quantities?
 

TRAIL-R3 (human) polyclonal antibody 

Flow Cytometry, ICC, IHC (PS), WB | Print as PDF
 
ALX-210-744-C200 200 µg 330.00 USD
Do you need bulk/larger quantities?
 

TRAIL-R3 (human) monoclonal antibody (LEIA) 

Flow Cytometry, WB | Print as PDF
 
ALX-804-136-C100 100 µg 320.00 USD
Do you need bulk/larger quantities?
 

TRAIL-R3 (human) monoclonal antibody (TR3.06) 

Flow Cytometry, IHC (PS), WB | Print as PDF
 
ALX-804-667-C100 100 µg 443.00 USD
Do you need bulk/larger quantities?
 

TRAIL-R3 (human) monoclonal antibody (DJR3) 

Flow Cytometry | Print as PDF
 
ALX-804-908-0100 100 µg 205.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
TRAIL receptor
By biological activity:
TRAIL receptor Monoclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Product Flyers
TRAIL & TRAIL Receptors
TRAIL & TRAIL Receptors
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,