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Cathepsin L/procathepsin L monoclonal antibody (CPLH 33/2)

ALX-804-291-C100 100 µg 510.00 USD
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Product Specification

Clone:CPLH 33/2
Immunogen:Purified human procathepsin L (from culture supernatant of non-small cell lung cancer cell line EPLC 32 M1).
UniProt ID:P07711 (cathepsin L1), O60911 (cathepsin L2)
Species reactivity:Human, Rat
Specificity:Recognizes the epitope G265YGFEST271 of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L.
Crossreactivity:Cross-reacts with rat cathepsin L and weakly with mouse procathepsin L. Does not cross-react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
Applications:ELISA, IHC (PS), WB
Recommended Dilutions/Conditions:ELISA (capture antibody)
Immunohistochemistry (paraffin sections after microwave treatment)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 0.01% thimerosal.
Handling:Do not freeze.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:Cathepsin L [EC] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.
LBS-AB-CL-2003 1
Figure 1: Epitope map of mature cathepsin L.

LBS-AB-CL-2003 5
Figure 5: Immunostaining with MAb to Cathepsin L (CPLH 33/2) of normal human lung epithelium (A) and alveolar macrophages (B). Courtesy of Dr. F. Buehling, Magdeburg
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LBS-AB-CL-2003 1 LBS-AB-CL-2003 5

Product Literature References

Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas: P. Wurl, et al.; Virchows Arch. 430, 221 (1997), Abstract;
Monoclonal antibodies against cathepsin L and procathepsin L of different species: E. Weber, et al.; Hybridoma 16, 159 (1997), Abstract;
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth: E. Weber, et al.; J. Cancer. Res. Clin. Oncol. 120, 564 (1994), Abstract;

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