Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Cathepsin L/procathepsin L monoclonal antibody (CPLH 33/2)

 
ALX-804-291-C100 100 µg 510.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Clone:CPLH 33/2
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Purified human procathepsin L (from culture supernatant of non-small cell lung cancer cell line EPLC 32 M1).
 
UniProt ID:P07711 (cathepsin L1), O60911 (cathepsin L2)
 
Species reactivity:Human, Rat
 
Specificity:Recognizes the epitope G265YGFEST271 of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L.
 
Crossreactivity:Cross-reacts with rat cathepsin L and weakly with mouse procathepsin L. Does not cross-react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
 
Applications:ELISA, IHC (PS), WB
 
Recommended Dilutions/Conditions:ELISA (capture antibody)
Immunohistochemistry (paraffin sections after microwave treatment)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.01% thimerosal.
 
Handling:Do not freeze.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:Cathepsin L [EC 3.4.22.15] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.
 
LBS-AB-CL-2003 1
Figure 1: Epitope map of mature cathepsin L.



LBS-AB-CL-2003 5
Figure 5: Immunostaining with MAb to Cathepsin L (CPLH 33/2) of normal human lung epithelium (A) and alveolar macrophages (B). Courtesy of Dr. F. Buehling, Magdeburg
Please mouse over
LBS-AB-CL-2003 1 LBS-AB-CL-2003 5

Product Literature References

Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas: P. Wurl, et al.; Virchows Arch. 430, 221 (1997), Abstract;
Monoclonal antibodies against cathepsin L and procathepsin L of different species: E. Weber, et al.; Hybridoma 16, 159 (1997), Abstract;
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth: E. Weber, et al.; J. Cancer. Res. Clin. Oncol. 120, 564 (1994), Abstract;

Product Toolbox

PRODUCT RESOURCES

Print as PDF
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Cathepsin
By biological activity:
Cathepsin Monoclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,