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Hepatitis C core protein monoclonal antibody (C7-50)

 
ALX-804-277-C100 100 µg 562.00 USD
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Product Specification

Clone:C7-50
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Purified HCV (hepatitis C virus) core fusion protein (genotype 1b).
 
Species reactivity:Hepatitis C virus
 
Specificity:Recognizes an epitope between aa 21-40 of HCV core protein. This sequence is conserved among different HCV strains.
 
Applications:ELISA, ICC, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Immunocytochemical staining of HCV core protein in transfected chimp hepatocytes yields a staining pattern consistent with cytoplasmic and vesicular staining.
Detects a band of ~21kDa by Western blot.
 
Formulation:Liquid. In PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Hepatitis C virus (HCV) is the primary cause of non-A, non-B hepatitis and results in most HCV-infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. The 21kDa core protein of HCV is well conserved among different HCV genotypes and may suppress hepatitis B virus replication in a phosphorylation dependent manner.
 

Product Literature References

Infection of Human Liver Myofibroblasts by Hepatitis C Virus: A Direct Mechanism of Liver Fibrosis in Hepatitis C: L. Aoudjehane, et al.; PLoS One 10, e0134141 (2015), Application(s): Western blot , Abstract; Full Text
Characterization of three novel monoclonal antibodies against hepatitis C virus core protein: D. Moradpour, et al.; J. Med. Virol. 48, 234 (1996), Abstract;

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