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PTEN monoclonal antibody (6H2.1)

 
ALX-804-254-C100 100 µg 668.00 USD
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Product Specification

Alternative Name:Phosphatase and tensin homolog deleted on chromosome 10
 
Clone:6H2.1
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Recombinant human PTEN.
 
UniProt ID:P60484
 
Species reactivity:Human, Mouse, Rat
 
Specificity:Recognizes an epitope between aa 304-403.
 
Applications:ELISA, ICC, IHC, IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (5µg)
Western Blot (1-5µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~60kDa by Western blot.
 
Purity Detail:Protein A-affinity purified. Sterile filtered.
 
Formulation:Liquid. In PBS.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
804-254
Figure: Left) PTEN non-expressing neoplastic endometrial glands in a background of normal expressing glands and stroma. Right) Single band specificity of MAb to PTEN 6H2.1 on PTEN expressing cancer cell lines.
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804-254

Product Literature References

Molecular identification of latent precancers in histologically normal endometrium: G.L. Mutter, et al.; Cancer Res. 61, 4311 (2001), Abstract; Full Text
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers: G.L. Mutter, et al.; J. Natl. Cancer Inst. 92, 924 (2000), Abstract;
Changes in endometrial PTEN expression throughout the human menstrual cycle: G.L. Mutter, et al.; J. Clin. Endocrinol. Metab. 85, 2334 (2000), Abstract; Full Text
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast: A. Perren, et al.; Am. J. Pathol. 155, 1253 (1999), Abstract; Full Text
PTEN suppresses breast cancer cell growth by phosphatase activity- dependent G1 arrest followed by cell death: L.P. Weng, et al.; Cancer Res. 59, 5808 (1999), Abstract; Full Text

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