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RANKL monoclonal antibody (12A668)

 
ALX-804-243-C100 100 µg 301.00 USD
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Product Specification

Alternative Name:ODF, TRANCE, OPGL, TNFSF 11, CD254
 
Clone:12A668
 
Host:Mouse
 
Isotype:IgG1 κ
 
Immunogen:Recombinant mouse RANKL (aa 1-317).
 
UniProt ID:O35235
 
Species reactivity:Human, Mouse
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~35-40kDa by Western blot.
Not suitable for flow cytometry.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
 
Use/Stability:Stable for 6 months when stored at +4°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:Replacement for ADI-AAM-425, see also ADI-AAM-425AF
 
804-243 1
Figure 1: Western blot analysis of RANKL in transfected cells using MAb to RANKL (12A668) (Prod. No. ALX-804-243).
804-243 2
Figure 2: Immunohistochemical staining of RANKL in formalin-fixed, paraffin embedded human lymph node using MAb to RANKL (Prod. No. ALX-804-243) at 5μg/ml. Hematoxylin-eosin counterstain.
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804-243 1 804-243 2

Product Literature References

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor: S. Niida, et al.; J. Biol. Chem. 279, 5752 (2004), Abstract; Full Text
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001), Abstract; Full Text
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors: T. Kikuchi, et al.; J. Immunol. 166, 3574 (2001), Abstract; Full Text
Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression: R.N. Pearse, et al.; PNAS 98, 11581 (2001), Abstract; Full Text

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