Recombinant human BCMA extracellular domain (aa 2-54) (Prod. No. ALX-522-026).
UniProt ID:
Q02223
Source:
Purified from ascites.
Species reactivity:
Human
Crossreactivity:
Does not cross-react with mouse BCMA.
Applications:
Flow Cytometry
Recommended Dilutions/Conditions:
Flow Cytometry (1:100) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Purity Detail:
Protein G-affinity purified.
Formulation:
Liquid. In PBS containing 0.02% sodium azide.
Handling:
Do not freeze. Protect from light.
Shipping:
Blue Ice Not Frozen
Short Term Storage:
+4°C
Long Term Storage:
+4°C
Scientific Background:
BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.
Regulatory Status:
RUO - Research Use Only
Flow cytometry analysis of 106 U266 cells stained using BCMA (human), mAb (Vicky-1) (PE conjugate) at a concentration of 10μg/ml.
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Product Literature References
Toll-like receptor 9 activation induces expression of membrane-bound B-cell activating factor (BAFF) on human B cells and leads to increased proliferation in response to both soluble and membrane-bound BAFF: E.Y. Abu-Rish, et al.; Rheumatology (Oxford) 52, 1190 (2013), Application(s): Flow Cytometry, Abstract; Full Text
Produced in HEK 293 cells. The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1., ≥95% (SDS-PAGE), ELISA, Flow Cytometry | Print as PDF
