Replaces Prod. #: ALX-804-151/1F
Product Specification
| Alternative Name: | B cell maturation protein, TNFRSF 17, CD269 |
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| Clone: | Vicky-1 |
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| Host: | Rat |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human BCMA extracellular domain (aa 2-54) (Prod. No. ALX-522-026). |
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| UniProt ID: | Q02223 |
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| Source: | Purified from ascites. |
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| Species reactivity: | Human
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| Crossreactivity: | Does not cross-react with mouse BCMA. |
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| Applications: | Flow Cytometry
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| Recommended Dilutions/Conditions: | Flow Cytometry (1:20 - 1:100 depending on cell type)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Handling: | Do not freeze. Protect from light. |
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| Shipping: | Blue Ice Not Frozen |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | +4°C |
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| Scientific Background: | BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation. |
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Product Literature References
Macrophage-mediated chronic lymphocytic leukemia cell survival is independent of APRIL signaling: M.H.A. van Attekum, et al.; Cell Death Discov.
2, 16020 (2016),
Application(s): Flow Cytometry,
Abstract;
Full Text
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