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DR6 (human) monoclonal antibody (Luke-1)

 
ALX-804-150-C100 100 µg 334.00 USD
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Product Specification

Alternative Name:Death receptor-6, TNFRSF 21
 
Clone:Luke-1
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Recombinant human DR6 (death receptor-6) (aa 42-335) (Prod. No. ALX-522-019).
 
UniProt ID:O75509
 
Source:Purified from concentrated hybridoma tissue culture supernatant.
 
Species reactivity:Human
 
Applications:Flow Cytometry
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors, TNF-R1 and Fas (CD95). Several death receptors including DR3, TRAIL-R1, and TRAIL-R2 were identified. A death domain containing receptor in the TNF-R family was cloned and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified yet. T cells from DR6-deficient mice showed preference toward Th2 differentiation in vitro, suggesting that DR6, working through JNK functions to attenuate the Th2 response. Other studies of DR6-targeted mutant mice demonstrated that DR6 functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses.
 
804-150
Figure: HEK 293T cells were mock transfected (thin line) or transfected with an expression plasmid coding for the extracellular domain of human DR6 (thick line).Method: Cells (5x105) were incubated on ice for 30 min. in 50µl FACS buffer (PBS, 5% FCS, 0.02% azide) containing 1µg/ml of anti-DR6 MAb (Luke-1). After washing in FACS buffer, R-PE-conjugated antibody to rat IgG was added. Cells were incubated on ice for 30 min., washed and analyzed by flow cytometry.
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804-150

General Literature References

Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice: J. Liu, et al.; Immunity 15, 23 (2001), Abstract;
Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice  : H. Zhao, et al.; J. Exp. Med. 194, 1441 (2001), Abstract; Full Text
Identification and functional characterization of DR6, a novel death domain-containing TNF receptor  : G. Pan, et al.; FEBS Lett 431, 351 (1998), Abstract;

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