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BAFF monoclonal antibody (Buffy-2) (FITC conjugate)

 
ALX-804-131F-T100 100 tests FITC 420.00 USD
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Product Specification

Alternative Name:B cell-activating factor, BLyS, TALL-1, THANK, zTNF4, TNFSF 13B/20, CD257
 
Clone:Buffy-2
 
Host:Rat
 
Isotype:IgM
 
Immunogen:Recombinant human soluble BAFF (aa 83-285) (Prod. No. ALX-522-025).
 
UniProt ID:Q9Y275
 
Species reactivity:Human
 
Specificity:Recognizes membrane-bound and soluble BAFF.
 
Crossreactivity:Weakly cross-reacts with mouse BAFF.
 
Applications:Flow Cytometry
 
Positive Control:For Positive Control (Western blot) see Prod. No. ALX-840-605.
 
Purity Detail:Purified by IgM purification HP column.
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Use/Stability:Stable for at least 6 months after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Technical Info/Product Notes:1 test means: 1µl of a 1mg/ml stock solution were used to stain 200'000 cells in a sample volume of 50µl.
 
804-131
Schematic structure of rhsBAFF (aa. 83-285). MAb to BAFF (Buffy-2) recognizes the TNF-homology domain.
804-131F FC
Flow cytometry analysis of 106 Jurkat cells were stained using BAFF, mAb (Buffy-2) fluorescein conjugate at a concentration of 50µg/ml.
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804-131 804-131F FC

Product Literature References

The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression: C.Y. Sun, et al.; Int. J. Rheumatol. 2013, 954292 (2013), Application(s): ELISA - Human Renal Specimens, Abstract; Full Text
Expression of TNF-superfamily members BAFF and APRIL in breast cancer: Immunohistochemical study in 52 invasive ductal breast carcinomas: V. Pelekanou, et al.; BMC Cancer 8, 76 (2008), Abstract; Full Text
In vitro and in vivo activation induces BAFF and APRIL expression in B cells: V.T. Chu, et al.; J. Immunol. 179, 5947 (2007), Abstract;
Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjogren’s syndrome: M.V. Jonsson, et al.; J. Clin. Immunol. 25, 189 (2005), Abstract;
Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt’s lymphoma: C.A. Ogden, et al.; J. Immunol. 174, 3015 (2005), Abstract; Full Text
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004), Abstract;
Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival: A. J. Novak, et al.; Blood 103, 689 (2004), Abstract;
Expression of BLyS and its Receptors in B-Cell Non-Hodgkin Lymphoma: Correlation with Disease Activity and Patient Outcome: A.J. Novak, et al.; Blood 104, 2247 (2004), Abstract;
Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL: B. He, et al.; J. Immunol. 172, 3268 (2004), Abstract; Full Text
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome: J. Groom, et al.; J. Clin. Invest. 109, 59 (2002), Abstract; Full Text

General Literature References

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice: S.D. Khare, et al.; PNAS 97, 3370 (2000), Abstract; Full Text
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth: P. Schneider, et al.; J. Exp. Med. 189, 1747 (1999), Abstract; Full Text
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator: P.A. Moore, et al.; Science 285, 260 (1999), Abstract;
Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kB, and c-Jun NH2-terminal kinase: A. Mukhopadhyay, et al.; J. Biol. Chem. 274, 15978 (1999), Abstract; Full Text
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations: F. Mackay, et al.; J. Exp. Med. 190, 1697 (1999), Abstract; Full Text
TALL-1 is a novel member of the TNF family that is down-regulated by mitogens: H.B. Shu, et al.; J. Leukoc. Biol. 65, 680 (1999), Abstract;

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Positive control (cell lysate), for antibodies to BAFF (human) 

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BAFF monoclonal antibody (Buffy-2) 

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