Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Clusterin (human) monoclonal antibody (CLI-9)

 
ALX-804-126-C100 100 µg 296.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:TRPM-2, SGP-2, CLI, Apolipoprotein J, CLU, APO-J
 
Clone:CLI-9
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Purified human clusterin (TRPM-2).
 
UniProt ID:P10909
 
Source:Purified from hybridoma tissue culture supernatant.
 
Species reactivity:Human
 
Applications:ICC, IHC (FS), IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 6 months after receipt when stored at +4°C undiluted.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.
 
Clusterin (human) monoclonal antibody (CLI-9) image
Please mouse over
Clusterin (human) monoclonal antibody (CLI-9) image

Product Literature References

MMP25 (MT6-MMP) Is Highly Expressed in Human Colon Cancer, Promotes Tumor Growth, and Exhibits Unique Biochemical Properties: Q. Sun, et al.; J. Biol. Chem. 282, 21998 (2007), Abstract; Full Text
Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent: T. Chen, et al.; Cancer Res. 64, 7412 (2004), Abstract; Full Text
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer  : C. D. Hough, et al.; Cancer Res. 60, 6281 (2000), Abstract;

General Literature References

Clusterin: S.E. Jones and C. Jomary; Int. J. Biochem. Cell Biol. 34, 427 (2002), (Review), Abstract;
Clusterin/Apolipoprotein J in human aging and cancer: I. Trougakos and E. Gonos; Int. J. Biochem. Cell Biol. 34, 1430 (2002), Abstract;
Clusterin: the intriguing guises of a widely expressed glycoprotein: D.E. Jenne & J. Tschopp; Trends Biochem. Sci. 17, 154 (1992), Abstract;
Apolipoprotein J: structure and tissue distribution: H.V. De Silva, et al.; Biochemistry 29, 5380 (1990), Abstract;
Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate: J.G. Leger, et al.; BBRC 147, 196 (1987), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Clusterin
By biological activity:
Clusterin Monoclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,