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Fas (DD) (human) monoclonal antibody (3D5)

 
ALX-804-119-R200 200 µl 356.00 USD
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Product Specification

Alternative Name:CD95, APO-1, TNFRSF 6
 
Clone:3D5
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human Fas (CD95; APO-1) cytoplasmic domain.
 
UniProt ID:P25445
 
Species reactivity:Human
 
Specificity:Recognizes the death domain (DD) of human Fas.
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:500; total cell lysates)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. In 50% glycerol containing 1mM sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Cisplatin augments FAS-mediated apoptosis through lipid rafts: C.R. Huang, et al.; Anticancer Res. 30, 2065 (2010), Abstract;
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling: C. Feig, et al.; EMBO J. 26, 221 (2007), Abstract; Full Text
Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB: K. Okamoto, et al.; Genes Cells 11, 177 (2006), Abstract; Full Text
Increase of Fas-induced apoptosis by inhibition of extracellular phosphorylation of Fas receptor in Jurkat cell line: C. Laurette, et al.; Apoptosis 11, 1195 (2006), Abstract;
Fas aggregation does not correlate with Fas-mediated apoptosis: Y. Lee & E. Shacter; J. Immunol. 167, 82 (2001), Abstract;
Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms: E.L. Henderson, et al.; Circulation 99, 96 (1999), Abstract; Full Text
Activation-induced aggregation and processing of the human Fas antigen. Detection with cytoplasmic domain-specific antibodies: T. Kamitani, et al.; J. Biol. Chem. 272, 22307 (1997), Abstract; Full Text

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