Ah receptor nuclear translocator, mAb (2B10)



ALX-804-108-R100	100 µl	345.00 USD

Product Specification

Alternative Name:	HIF-1β, ARNT, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1β

Concentration:	1mg/ml

Formulation:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.

Clone:	2B10

Isotype:	Mouse IgG1

Immunogen:	Synthetic peptide corresponding to aa 771-789 (N⁷⁷¹SYNNEEFPDLTMFPPFSE⁷⁸⁹) of human ARNT (Ah receptor nuclear translocator).

Specificity:	Recognizes human, mouse, rat and monkey ARNT. Detects a band of ~87kDa by Western blot.

Application:	Gel Shift Assay Immunocytochemistry (1:1’000) Immunoprecipitation Western Blot (1:4’000)

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Product Literature References

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor: G. Höpfl, et al.; Cancer Res. 62, 2962 (2002), Abstract; Full Text

The arylhydrocarbon receptor (AhR), but not the AhR-nuclear translocator (ARNT), is increased in hearts of patients with cardiomyopathy: M.R. Mehrabi, et al.; Virchows Arch. 441, 481 (2002), Abstract; Full Text

A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses: Y.S. Chun, et al.; J. Cell Sci. 114, 4051 (2001), Abstract; Full Text

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia: H. Suzuki, et al.; Oncogene 20, 5779 (2001), Abstract; Full Text

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression: T. Sanchez-Elsner, et al.; J. Biol. Chem. 276, 38527 (2001), Abstract; Full Text

DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms: H. Yin and K.L. Blanchard; Blood 95, 111 (2000), Abstract; Full Text

Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha: D. Chilov, et al.; J. Cell Sci. 112, 1203 (1999), Abstract; Full Text

Oxygen tension modulates beta-globin switching in embryoid bodies: S. Bichet, et al.; FASEB J. 13, 285 (1999), Abstract; Full Text

Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context: W.P. Long, et al.; J. Biol. Chem. 274, 12391 (1999), Abstract; Full Text

Physiochemical and immunocytochemical analysis of the aryl hydrocarbon receptor translocator: Characterization of two monoclonal antibodies to the ARNT: N.G. Hord & G. Perdew; Mol. Pharmacol. 46, 618 (1994), Abstract;