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Mineralocorticoid (aldosterone) receptor monoclonal antibody (H10E4C9F)

 
ALX-804-099-R100 100 µl 578.00 USD
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Product Specification

Alternative Name:MR
 
Clone:H10E4C9F
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Aldosterone.
 
UniProt ID:P08235 (human), P22199 (rat)
 
Source:Produced using the anti-idiotypic method.
 
Species reactivity:Human, Rat
Chicken, Rabbit
 
Applications:ICC, IHC (PS), WB, FUNC
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1:100; staining is blocked by pre-incubating the sample with aldosterone)
Western Blot (1:1,000; ECL: Enhanced detection systems like enhanced chemiluminescence are recommended).
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~116kDa by Western blot.
Functional Application: Blocks the binding of aldosterone to the MR.
Not suitable for immunoprecipitation.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. Purified ascites in PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Pituitary expression of type I and type II glucocorticoid receptors during chicken embryonic development and their involvement in growth hormone cell differentiation: I. Bossis, et al.; Endocrinology 145, 3523 (2004), Abstract; Full Text
Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action: G. Li, et al.; J. Biol. Chem. 278, 41779 (2003), Abstract; Full Text
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development: M. Kingsley-Kallesen, et al.; Mol. Endocrinol. 16, 2008 (2002), Abstract; Full Text
Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart: M. Lombes, et al.; Circulation 92, 175 (1995), Abstract; Full Text
Aldosterone antagonists destabilize the mineralocorticosteroid receptor: B. Couette, et al.; Biochem. J. 282, 697 (1992), Abstract;
Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor: M. Lombes, et al.; Circ. Res. 71, 503 (1992), Abstract;
Immunohistochemical localization of renal mineralocorticoid receptor by using an anti-idiotypic antibody that is an internal image of aldosterone: M. Lombes, et al.; PNAS 87, 1086 (1990), Abstract; Full Text
Internal image properties of a monoclonal auto-anti-idiotypic antibody and its binding to aldosterone receptors: M. Lombes, et al.; J. Biol. Chem. 264, 2528 (1989), Abstract; Full Text

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Aldosterone receptor
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