Enhancer for Ligands

Enhances biological activity of TRAIL, soluble (human) (recombinant) and FasL, soluble (human) (recombinant).



ALX-804-034-C050	50 µg	287.00 USD
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Negative control in experiments with recombinant proteins fused to human IgG1 Fc.

Product Specification

Concentration:	1mg/ml after reconstitution.

Endotoxin Content:	<0.1EU/µg purified protein (LAL test; Lonza)

Purity:	≥95% (SDS-PAGE)

Formulation:	Lyophilized. Contains PBS.

Reconstitution:	Reconstitute with 50µl sterile water.

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	PBS containing at least 0.1% BSA should be used for further dilutions. Stable for at least 6 months after receipt when stored at -20°C.

Handling:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Literature References

Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses: D. Fabricius, et al.; Leukemia 25, 1111 (2011), Abstract;

Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human Bcells: Differential effects of BMP-6 and BMP-7: K. Huse, et al.; Eur. J. Immunol. 41, 3135 (2011), Abstract;

Autoantibody-producing RP105(-) B cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects: S. Koarada, et al.; Rheumatology (Oxford) 49, 662 (2010), Abstract; Full Text

Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects: E. Margolles-Clark, et al.; Biochem. Pharmacol. 77, 1236 (2009), Abstract;

CD40 activation in human pancreatic islets and ductal cells: D. Klein, et al.; Diabetologia 51, 1853 (2008), Abstract; Full Text

Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis: E. Kump, et al.; Oncogene 27, 3856 (2008), Abstract;

The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells: M. Luqman, et al.; Blood 112, 711 (2008), Abstract; Full Text

Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003), Abstract; Full Text