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TPPP monoclonal antibody (17C6)

 
ALX-803-342-C100 100 µg 291.00 USD
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Product Specification

Alternative Name:Tubulin polymerization-promoting protein, p25
 
Clone:17C6
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Full lenght recombinant TPPP.
 
UniProt ID:O94811
 
Source:Purified from concentrated hybridoma tissue culture supernatant.
 
Species reactivity:Human, Mouse
Monkey
 
Specificity:Recognizes full-length endogenous TPPP/p25.
 
Applications:ICC, IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Immunohistochemistry (paraffin sections, 10µg/ml)
Western Blot (200ng/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:TPPP plays a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. Plays a role in mitotic spindle assembly and nuclear envelope breakdown.
 

Product Literature References

The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules: K. Acevedo, et al.; Exp. Cell Res. 313, 4091 (2007), Abstract;

General Literature References

Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis: R. Hofberger, et al.; Glia 58, 1847 (2010), Abstract;

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