Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

c-IAP2 monoclonal antibody (human) (16E-6-3)

 
ALX-803-341-C100 100 µg 269.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:HIAP-1, BIRC3, Baculoviral IAP repeat-containing protein-3, Cellular inhibitor of apoptosis-2, Human inhibitor of apoptosis protein-1, RNF49, API2
 
Clone:16E-6-3
 
Host:Rat
 
Isotype:IgG1
 
Immunogen:GST-fusion product of the CARD domain of human c-IAP2.
 
UniProt ID:Q13489
 
Species reactivity:Human
 
Crossreactivity:Does not cross-react with mouse c-IAP2. Does not cross-react with human or mouse c-IAP1.
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:500-1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. 0.2µm-filtered solution in PBS containing 50% glycerol.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-80°C
 
Scientific Background:The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 aa BIR (baculovirus inhibitor repeat) domain. Human members of the family include c-IAP1, c-IAP2, XIAP, survivin, livin and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7 and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks its interaction with caspase-9, thereby allowing the processing and activation of the caspase.
 

Product Literature References

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2: M. Darding, et al.; Cell Death Differ. 18, 1376 (2011), Abstract; Full Text
TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL: J.M. Lluis, et al.; PLoS One 5, e8620 (2010), Abstract; Full Text
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment: P. Geserick, et al.; J. Cell Biol. 187, 1037 (2009), Abstract; Full Text
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced : J.E. Vince, et al.; J. Biol. Chem. 284, 35906 (2009), Abstract;
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha: J.E. Vince, et al.; J. Cell. Biol. 182, 171 (2008), Abstract; Full Text
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis: J.E. Vince, et al.; Cell 131, 682 (2007), Abstract;
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance: J. Silke, et al.; PNAS 102, 16182 (2005), Abstract; Full Text

General Literature References

Destabilizing influences in apoptosis: sowing the seeds of IAP destruction: S.J. Martin; Cell 109, 793 (2002), Review, Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
IAP
By biological activity:
IAP Monoclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,