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MD-2 (human) monoclonal antibody (4H1)

 
ALX-803-325-C100 100 µg 300.00 USD
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Product Specification

Alternative Name:LY96, Lymphocyte antigen 96, ESOP-1
 
Clone:4H1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human MD-2.
 
UniProt ID:Q9Y6Y9
 
Source:Purified from concentrated hybridoma tissue culture supernatant.
 
Species reactivity:Human
 
Specificity:Recognizes all forms of soluble human MD-2, but not membrane bound MD-2.
 
Crossreactivity:Does not cross-react with mouse MD-2.
 
Applications:ELISA, WB
 
Application Notes:Functional Application: inhibits binding of MD-2 to lipolysaccharide (LPS)
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide.
 

Product Literature References

Characterization of monoclonal antibodies to human soluble MD-2 protein: S. Viriyakosol, et al.; Hybridoma 25, 349 (2006), Abstract;

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