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Laminin (α4-chain) (human) monoclonal antibody (651C2)

 
ALX-803-310-R100 100 µl 260.00 USD
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Product Specification

Clone:651C2
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human laminin α4 subunit (G1-G3 domains).
 
UniProt ID:Q16363
 
Species reactivity:Human
 
Specificity:Recognizes an epitope within the G1-G3 domains of laminin α4 subunit.
 
Applications:ELISA, IHC (FS)
 
Recommended Dilutions/Conditions:ELISA (1:500-1:2,000)
Immunohistochemistry (frozen sections, 1:100-1:300)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Ascites.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The laminins are a family of glycoproteins that provide an integral part of the structural scaffolding of basement membranes in almost every tissue. Each laminin is a heterotrimer assembled from α, β and γ chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycans, and other receptors. Through these interactions, laminins critically contribute to cell differentiation, cell shape and movement, maintenance of tissue phenotypes and promotion of tissue survival.
 

Product Literature References

Laminin isoforms 8 and 10 are primary components of the subendothelial basement membrane promoting interaction with neoplastic lymphocytes: P. Spessotto, et al.; Cancer Res. 61, 339 (2001), Abstract; Full Text

General Literature References

Physiological and pathological implications of laminins: from the gene to the protein: M.C. Paez, et al.; Autoimmunity 40, 83 (2007), (Review), Abstract;
Laminin-induced signaling in tumor cells: V. Givant-Horwitz, et al.; Cancer Lett. 223, 1 (2005), (Review), Abstract;
Laminin: the crux of basement membrane assembly: T. Sasaki, et al.; J. Cell. Biol. 164, 959 (2004), (Review), Abstract; Full Text
Form and function: the laminin family of heterotrimers: H. Colognato & P.D. Yurchenko; Dev. Dyn. 218, 213 (2000), (Review), Abstract; Full Text

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