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CD51 (human) monoclonal antibody (L230)

 
ALX-803-304-C100 100 µg 281.00 USD
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Product Specification

Alternative Name:αV integrin, Vitronectin receptor α subunit
 
Clone:L230
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human endothelial cells.
 
UniProt ID:P06756
 
Species reactivity:Human
 
Specificity:Recognizes heterodimers αVβ3, αVβ1, αVβ5 and αVβ6.
 
Crossreactivity:Does not cross-react with other species.
 
Applications:ELISA, Flow Cytometry, IF, IHC, IP, FUNC
 
Application Notes:Functional Application: αV integrin blocking
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.
 

Product Literature References

Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion: J. Nevo, et al.; Oncogene 29, 6452 (2010), Abstract;
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells: S. Tuomi, et al.; Sci. Signal. 2, ra32 (2009), Abstract; Full Text
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9: C.H. Williams, et al.; J. Virol. 78, 6967 (2004), Abstract; Full Text
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading: P. Di Stefano, et al.; Mol. Biol. Cell 15, 787 (2004), Abstract; Full Text
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines: L. Moro, et al.; J. Biol. Chem. 277, 9405 (2002), Abstract; Full Text
A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells: B.R. Schwartz, et al.; J. Immunol. 162, 4842 (1999), Abstract; Full Text
Role of the Integrin avp6 in Cell Attachment to Fibronect: A. Weinacker, et al.; J. Biol. Chem. 269, 6940 (1994), Application(s): IP using human SK-Mel-19, MG-63, HeLa, and FG cell lysates; alphav integrin blocking using human 293, MG-63, FG and SW480beta6 cells, Abstract; Full Text

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