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p130Cas monoclonal antibody (1H9)

 
ALX-803-300-C100 100 µg 220.00 USD
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Product Specification

Alternative Name:CRK-associated substrate, CRKAS, Breast cancer estrogen resistance 1 protein, BCAR1
 
Clone:1H9
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant mouse p130Cas (CRK-associated substrate; BCAR1) C-terminal portion (aa 375-630).
 
UniProt ID:Q61140
 
Species reactivity:Human, Mouse, Rat
 
Applications:ELISA, ICC, IHC (FS), IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (5µl per 5x106 cells)
Western Blot (1:20,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

p130Cas as a New Regulator of Mammary Epithelial Cell Proliferation, Survival, and HER2-Neu Oncogene– Dependent Breast Tumorigenesis: S. Cabodi, et al.; Cancer Res. 66, 4672 (2006), Abstract;
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells: S. Cabodi, et al.; J. Cell Sci. 117, 1603 (2004), Abstract;

General Literature References

p130Cas is required for mammary tumor growth and transforming growht factor-β (TGF-β)-mediated metastasis through regulation of smad2/3 activity: M.K. Wendt, et al.; J. Biol. Chem. (2009), Abstract;

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