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NS5B (HCV) monoclonal antibody (5B-3B1)

ALX-803-060-C100 100 µg 485.00 USD
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Product Specification

Immunogen:Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Source:Purified from concentrated hybridoma tissue culture supernatant.
Species reactivity:Hepatitis C virus
Specificity:Epitope mapped to NS5B aa 372-382.
Recognizes genotype 1a and 1b (with lower affinity) and does not recognize genotype 2a.
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C

Product Literature References

Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3: Y.V. Svitkin, et al.; J. Virol. 79, 6868 (2005), Abstract; Full Text
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids: S.B. Kapadia and F.V. Chisari; PNAS 102, 2561 (2005), Abstract; Full Text
Quantitative analysis of the hepatitis C virus replication complex: D. Quinkert, et al.; J. Virol. 79, 13594 (2005), Abstract;
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs: G. Randall, et al.; PNAS 100, 235 (2003), Abstract; Full Text
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells: R.W. Hardy, et al.; J. Virol. 77, 2029 (2003), Abstract; Full Text
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase: D. Moradpour, et al.; J. Biol. Chem. 277, 593 (2002), Abstract; Full Text

General Literature References

Unravelling hepatitis C virus replication from genome to function: B.D. Lindenbach and C.M. Rice; Nature 436, 933 (2005), Abstract;

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