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Furin convertase (human) monoclonal antibody (MON-152)

 
ALX-803-017-R100 100 µl 323.00 USD
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Product Specification

Clone:MON-152
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human furin.
 
UniProt ID:P09958
 
Source:Ascites fluid from Balb/c mice as obtained after injection of MON-152 producing hybridoma cells and isolated using a physiological salt solution (0.9% NaCl).
 
Species reactivity:Human
 
Specificity:Recognizes an epitope in the cysteine-rich region of human furin convertase.
 
Crossreactivity:Does not cross-react with mouse furin convertase.
 
Applications:ICC, IP, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:200-1:400)
Immunoprecipitation (1:200; 50mM TRIS/HCl, pH 7.4, 150mM NaCl, 1% Triton X-100, 1% sodium deoxycholate, 0.1% SDS)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Ascites. Contains no preservatives.
 
Use/Stability:Stable for at least 3 months when stored at +4°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Mechanism and significance of cell type-dependent neutralization of flaviviruses: S. Mukherjee, et al.; J. Virol. 88, 7210 (2014), Application(s): Western blot, Abstract; Full Text
Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii: A. Oksanen, et al.; J. Immunol. 193, 5470 (2014), Abstract;
Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor: D. Urban, et al.; J. Biochem. 153, 197 (2013), Abstract;
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity: K. Kappert, et al.; PLoS One 8, e70542 (2013), Application(s): Western blot, Abstract; Full Text
Generation and characterization of non-competitive furin-inhibiting nanobodies: J. Zhu, et al.; Biochem. J. 448, 73 (2012), Application(s): IP, Abstract; Full Text
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL: H. Turpeinen, et al.; Atherosclerosis 219, 799 (2011), Application(s): Immunohistochemistry, Abstract;
Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway: S.A. Brown, et al.; J. Biol. Chem. 285, 17432 (2010), Application(s): Western blot, Abstract; Full Text
IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling: V. Furundzija, et al.; Biochem. Biophys. Res. Commun. 394, 786 (2010), Application(s): Western blot, Abstract;
Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7: R.M. Leonhardt, et al.; J. Immunol. 184, 2985 (2010), Application(s): Immunofluorescence, Abstract; Full Text
Cell-surface processing of pro-ADAMTS9 by furin: B.H. Koo, et al.; J. Biol. Chem. 281, 12485 (2006), Abstract; Full Text
The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin: E.K. Dufour, et al.; J. Biol. Chem. 276, 38971 (2001), Abstract; Full Text
Processing, stability, and receptor binding properties of oligomeric envelope glycoprotein from a primary HIV-1 isolate: I. Staropoli, et al.; J. Biol. Chem. 275, 35137 (2000), Abstract; Full Text
Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase: J.W. van de Loo; J. Biol. Chem. 272, 27116 (1997), Abstract; Full Text
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum: J.W. Creemers, et al.; J. Biol. Chem. 270, 2695 (1995), Abstract; Full Text
Modulation of furin-mediated proprotein processing activity by site- directed mutagenesis: J.W. Creemers, et al.; J. Biol. Chem. 268, 21826 (1993), Abstract; Full Text
Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases: W.J. Van de Ven, et al.; Crit. Rev. Oncog. 4, 115 (1993), Abstract;
Development and characterization of a panel of monoclonal antibodies against the novel subtilisin-like proprotein processing enzyme furin: H.L. van Duijnhoven, et al.; Hybridoma 11, 71 (1992), Abstract;

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