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Progesterone receptor monoclonal antibody (αPR6)

 
ALX-803-010-C100 100 µg 389.00 USD
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Product Specification

Alternative Name:PR
 
Clone:αPR6
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Purified chicken PR (progesterone receptor).
 
UniProt ID:P07812
 
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Guinea pig, Rabbit, Sheep
 
Specificity:Recognizes the B form of PR.
 
Crossreactivity:Does not cross-react with ER (estrogen receptor) or GR (glucocorticoid receptor).
 
Applications:ICC, IHC (FS), IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (frozen sections, 20µg/ml)
Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~110kDa in chicken and rabbit, and a doublet or triplet band of ~120kDa in human by Western blot.
 
Purity Detail:Purified IgG2a from ascites.
 
Formulation:Lyophilized. Contains 0.05% sodium azide.
 
Reconstitution:Reconstitute with PBS.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Avian and mammalian PR isolated from tissue soluble extracts can exist in one of two different molecular forms A and B. Human PR consists of a 94kDa A form and a 120kDa B form. Chicken PR consists of a 78kDa A form and a 110kDa B form. Alpha PR6 reacts with both the 120kDa B form of human PR and the 110kDa B form of chicken PR.
 

Product Literature References

Ovine uterine gland knock-out model: effects of gland ablation on the estrous cycle: C. Allison Gray, et al.; Biol. Reprod. 62, 448 (2000), Abstract; Full Text

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