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Glucocorticoid receptor monoclonal antibody (BuGR2)

 
ALX-803-006-C100 100 µg 418.00 USD
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Product Specification

Alternative Name:GR
 
Clone:BuGR2
 
Host:Mouse
 
Isotype:IgG2
 
Immunogen:Partially purified rat GR (glucocorticoid receptor).
 
UniProt ID:P06536
 
Species reactivity:Human, Mouse, Rat
Guinea pig, Rabbit, Sheep, Yeast
 
Specificity:Recognizes full-lengh GR, the 17kDa DNA binding trypsin fragment and the 45kDa steroid- and DNA-binding chymotrypsin fragment.
 
Crossreactivity:Does not cross-react with primate, avian or amphibian GR.
 
Applications:Flow Cytometry, ICC, IHC (PS), IP, WB
Gel Shift
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (5µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Immunocytochemical staining of GR in L929 cells with Prod. No. ALX-803-006 results in staining of both the cytoplasm and nucleus, even in the presence of hormone.
Detects a band of ~97kDa by Western blot.
 
Formulation:Lyophilized from PBS, pH 7.2, containing 0.05% sodium azide.
 
Reconstitution:Reconstitute with distilled water.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
803-006
Figure: Western blot analysis of glucocorticoid receptor on mouse liver extract using Prod. No. ALX-803-006.
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803-006

Product Literature References

Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation: S.L. Wyszomierski, et al.; Mol. Endocrinol. 13, 330 (1999), Abstract; Full Text
Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes: R.L. Barent, et al.; Mol. Endocrinol. 12, 342 (1998), Abstract; Full Text
Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid: H.P. Dao-Phan, et al.; Mol. Endocrinol. 11, 962 (1997), Abstract; Full Text
Phosphorylated sites within the functional domains of the approximately 100-kDa steroid-binding subunit of glucocorticoid receptors: L.I. Smith, et al.; Biochemistry 28, 4490 (1989), Abstract;
Analysis of the disruptive action of an epididymal protease and the stabilizing influence of molybdate on nondenatured and denatured glucocorticoid receptor: W.J. Hendry, 3rd, et al.; Endocrinology 120, 629 (1987), Abstract;

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