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GCDFP-15 (human) monoclonal antibody (D6)

 
ALX-801-051-L001 1 ml 862.00 USD
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Product Specification

Alternative Name:BRST-2
 
Clone:D6
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:GCDFP-15 (gross cystic disease fluid protein-15; BRST-2).
 
UniProt ID:P12273
 
Species reactivity:Human
 
Applications:IHC (PS)
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections): Formalin-fixed, paraffin-embedded tissues; pre-treatment not required; suggested dilution: ≥1:40 for biotin based detection. For optimal staining, incubate primary antibody 20-60 minutes at room temperature).
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:This antibody is heat sensitive. Paraffin sections that have been heat fixed at 60°C may lose antibody binding site.
 
Positive Control:Human axilla or breast carcinoma.
 
Formulation:Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide .
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15kDa monomer protein, GCDFP-15. The cells within the body that produce GCDFP-15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP-15 to be a highly specific and sensitive marker for breast cancer.
GCDFP-15 is expressed by apocrine sweat glands, eccrine glands (variable), minor salivary glands, bronchial glands, metaplasmic epithelium of the breast, benign sweat gland tumors of the skin and the serous cells of the submandibular gland. Breast carcinomas (primary and metastatic lesions) with apocrine features express GCDFP-15. GCDFP-15 is positive in extramammary Paget's Disease. Other tumors tested are negative.
 

Product Literature References

Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature: C.Y. Fan, et al.; Am. J. Surg. Pathol. 24, 579 (2000), Abstract;
Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin: M.R. Wick, et al.; Hum. Pathol. 20, 281 (1989), Abstract;
Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins: G. Mazoujian, et al.; Am. J. Surg. Pathol. 8, 43 (1984), Abstract;
Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features: G. Mazoujian, et al.; Am. J. Pathol. 110, 105 (1983), Abstract;

General Literature References

C.D. Haagensen; Disease of the breast. 3rd edition. W.B. Saunders Co. Philadelphia, PA. 250 (1986),

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