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Breast cancer resistance protein (human) monoclonal antibody (BXP-21)

 
ALX-801-029-C125 125 µg 453.00 USD
 
ALX-801-029-C250 250 µg 788.00 USD
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Product Specification

Alternative Name:MXR, BCRP, ABCG2, CD338
 
Clone:BXP-21
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Recombinant human BCRP (breast cancer resistance protein; MXR) (aa 271-396).
 
UniProt ID:Q9UNQ0
 
Species reactivity:Human
 
Specificity:Recognizes an internal epitope of human BCRP.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MRP1 or MRP2.
 
Applications:ICC, IHC (FS), IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex.
Immunohistochemistry (paraffin sections): Use on formaldehyde-fixed paraffin-embedded human tissues and tumors after pretreatment with 10mM citric acid, pH 6.0, for 20 min.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
 
Application Notes:Immunocytochemistry: cytospin preparations
 
Formulation:Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate: K. Sayyed, et al.; Toxicology 363, 58 (2016), Application(s): Cell culture; Effects on ABC transporter activities, Abstract;
The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport: S. Macalou, et al.; Cell Mol. Life Sci. 73, 1927 (2016), Application(s): Western Blot, Immunostaining, Abstract; Full Text
The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters: J.P. Rigalli, et al.; Cancer Lett. 376, 165 (2016), Application(s): Western blot, Abstract;
The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures: E. Sieppi, et al.; Mol. Cell. Endocrinol. 429, 41 (2016), Application(s): Immunoblotting, Abstract;
Protein kinase C-dependent regulation of human hepatic drug transporter expression: A. Mayati, et al.; Biochem. Pharmacol. 98, 703 (2015), Application(s): Western Blot, Abstract;
Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier: B. Poller, et al.; Cell. Mol. Neurobiol. 30, 63 (2010), Abstract;
Characterization of Drug Transport, ATP Hydrolysis, and Nucleotide Trapping by the Human ABCG2 Multidrug Transporter : C. Özvegy, et al.; J. Biol. Chem. 277, 47980 (2002), Abstract; Full Text
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues: M. Maliepaard, et al.; Cancer Res. 61, 3458 (2001), Abstract; Full Text

General Literature References

A multidrug resistance transporter from human MCF-7 breast cancer cells: L.A. Doyle, et al.; PNAS 95, 15665 (1998), Abstract; Full Text

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