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Breast cancer resistance protein (human) monoclonal antibody (BXP-34)

 
ALX-801-027-C125 125 µg 441.00 USD
 
ALX-801-027-C250 250 µg 788.00 USD
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Product Specification

Alternative Name:MXR, BCRP, ABCG2, CD338
 
Clone:BXP-34
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Mitoxanthone resistant BCRP (breast cancer resistance protein; MXR) overexpressing cell line MCF7MR.
 
UniProt ID:Q9UNQ0
 
Species reactivity:Human
 
Specificity:Recognizes an internal epitope of human BCRP.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MRP1, MRP2 or MRP5.
 
Applications:Flow Cytometry, ICC, IHC (FS)
 
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution of BXP-34 on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. BXP-34 cannot be used on formaldehyde-fixed paraffin-embedded human tissues and tumors.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
 
Application Notes:Immunocytochemistry: cytospin preparations
Not recommended for Western blot.
 
Formulation:Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate: M. Studzian, et al.; Biochim. Biophys. Acta 1853, 1759 (2015), Application(s): Immunofluorescence, Abstract;
The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003), Abstract;
Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia: J.M. Sargent, et al.; Br. J. Haematol. 115, 257 (2001), Abstract;
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues: M. Maliepaard, et al.; Cancer Res. 61, 3458 (2001), Abstract; Full Text
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines: G.L. Scheffer, et al.; Cancer Res. 60, 2589 (2000), Abstract; Full Text

General Literature References

A multidrug resistance transporter from human MCF-7 breast cancer cells: L.A. Doyle, et al.; PNAS 95, 15665 (1998), Abstract; Full Text

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