Breast cancer resistance protein (human), mAb (BXP-34)



ALX-801-027-C125	125 µg	407.00 USD

ALX-801-027-C250	250 µg	691.00 USD

Product Specification

Alternative Name:	MXR, BCRP, ABCG2, CD338

Concentration:	~250µg/ml

Formulation:	Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Clone:	BXP-34

Isotype:	Mouse IgG1

Immunogen:	Mitoxanthone resistant BCRP (breast cancer resistance protein; MXR) overexpressing cell line MCF7MR.

Specificity:	Recognizes an internal epitope of human BCRP. Does not cross-react with human P-glycoprotein, MRP1, MRP2 or MRP5.

Application:	Flow Cytometry Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations. Immunohistochemistry (frozen sections): Use 1:20 dilution of BXP-34 on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. BXP-34 cannot be used on formaldehyde-fixed paraffin-embedded human tissues and tumors. Not recommended for Western blot.

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Product Literature References

The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003), Abstract;

Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia: J.M. Sargent, et al.; Br. J. Haematol. 115, 257 (2001), Abstract;

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues: M. Maliepaard, et al.; Cancer Res. 61, 3458 (2001), Abstract; Full Text

Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines: G.L. Scheffer, et al.; Cancer Res. 60, 2589 (2000), Abstract; Full Text