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MVP/LRP (human) monoclonal antibody (MVP-37)

ALX-801-026-C125 125 µg 301.00 USD
ALX-801-026-C250 250 µg 460.00 USD
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Product Specification

Alternative Name:Major vault protein/Lung resistance protein
Immunogen:Human MVP/LRP (major vault protein/lung resistance protein).
UniProt ID:Q14764
Species reactivity:Human
Specificity:Recognizes an internal epitope of human MVP/LRP, which is strongly overexpressed in various non-P-glycoprotein MDR tumor cell lines.
Applications:IHC (FS), IHC (PS), WB
Recommended Dilutions/Conditions:Immunohistochemistry (frozen sections, paraffin sections): use approx. 1:20-50 dilution for staining of paraformaldehyde (4%) fixed cytospin preparations or frozen tissue sections. Apply the following pretreatment: 10 min in 20mM glycine (pH 7.5) and 10 min in 6N guanidine hydrochloride in 50mM Tris-HCl, pH 7.5 (Schroeijers et al., (2000))
Western Blot: use 1:50 dilution of MVP-37 (ECL)
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C

Product Literature References

Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines: R. Januchowski, et al.; J. Ovarian Res. 9, 65 (2016), Application(s): Immunofluorescence analysis, human ovarian carcinoma cell line A2780, Abstract; Full Text
Up-regulation of drug resistance-related vaults during dendritic cell development: A.B. Schroeijers, et al.; J. Immunol. 168, 1572 (2002), Abstract;
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies: A.B. Schroeijers, et al.; J. Histochem. Cytochem. 49, 1379 (2001), Abstract;
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines: A.B. Schroeijers, et al.; Cancer Res. 60, 1104 (2000), Abstract; Full Text

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