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MRP2 (human) monoclonal antibody (M2I-4)

 
ALX-801-015-C250 250 µg 788.00 USD
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Product Specification

Alternative Name:Multidrug resistance-associated protein 2, cMOAT, ABCC2
 
Clone:M2I-4
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human MRP2 (multidrug resistance-associated protein 2; cMOAT) (aa 215-310).
 
UniProt ID:Q92887
 
Species reactivity:Human
 
Specificity:Recognizes an internal epitope of human MRP2.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP3 or MRP5. Does not cross-react with mouse, rat or guinea pig MRP2.
 
Applications:ICC, IHC (FS), WB
 
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Or, after incubation with the primary antibody and washing, slides can be incubated with biotinylated rabbit anti-mouse IgG and streptavidin conjugated to horseradish peroxidase.
Western Blot: Use 1:20-1:50 dilution and anti-mouse-HRP.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
 
Application Notes:Immunohistochemistry: Suitable for frozen sections, weak in paraffin sections.
 
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Exon-skipping and mRNA decay in human liver tissue: molecular consequences of pathogenic bile salt export pump mutations: C. Droge, et al.; Sci. Rep. 6, 24827 (2016), Application(s): Immunofluorescence of liver tissue, Abstract;
Functional Defect of Variants in the ATP-binding Sites of ABCB4 and their Rescue by the CFTR Potentiator, Ivacaftor (VX-770): J. Delaunay, et al.; Hepatology (2016),
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text

General Literature References

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines: M. Kool, et al.; Cancer Res. 57, 3537 (1997), Abstract;
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene: C.C. Paulusma, et al.; Science 271, 1126 (1996), Abstract;

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