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MRP1 (human) monoclonal antibody (MRPm6)

ALX-801-013-C250 250 µg 440.00 USD
ALX-801-013-C500 500 µg 799.00 USD
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Product Specification

Alternative Name:Multidrug resistance-associated protein 1, ABCC1
Immunogen:Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 1294-1531).
UniProt ID:P33527
Species reactivity:Human
Specificity:Recognizes the internal epitope (P1511SDLLQQRGL1520) of human MRP1.
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP5.
Applications:Flow Cytometry, ICC, IHC (FS), WB
Recommended Dilutions/Conditions:Suggested starting dilution is 1:20
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
Immunohistochemistry: Suitable for frozen sections, weak in paraffin sections.
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Figure: Epitope Mapping of MAbs MRPr1, QCRL-1 & MRPm6. Topological model of MRPdepicting the approx. locations of the MRPr1, QCRL-1 and MRPm6 epitopes. The model shown is only one of several possible configurations. MSD=membrane spanning domain; NBD=nucleotide binding domain. From R. Hipfner, et al.; Br. J. Cancer 78,1134 (1998).
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Product Literature References

Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1: L. Dury, et al.; Biochem. Pharmacol. 124, 10 (2017), Application(s): Western blot, BHK-21 cells, Abstract;
Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β: E. Roundhill, et al.; FASEB J. 30, 1712 (2016), Abstract;
Dimethyl sulfoxide induces chemotherapeutic resistance in the treatment of testicular embryonal carcinomas: H. Kita, et al.; Oncol. Lett. 10, 661 (2015), Application(s): Western blot, Abstract; Full Text
Flow cytometric assessment of P-glycoprotein and multidrug resistance-associated protein activity and expression in canine lymphoma: B. Pozniak, et al.; In Vivo 29, 149 (2015), Abstract;
Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy: C. Luna-Tortos, et al.; Neuropharmacology 58, 1019 (2010), Abstract;
(R)- and (S)-Verapamil Differentially Modulate the Multidrug-resistant Protein MRP1: T. Perrotton, et al.; J. Biol. Chem. 282, 31542 (2007), Abstract; Full Text
Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart: A. Rosati, et al.; Anticancer Res. 20, 3403 (2000), Abstract;
Expression of the multidrug resistance-associated protein in myelodysplastic syndromes: S. Poulain, et al.; Br. J. Haematol. 110, 591 (2000), Abstract;
Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract;
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text
The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract;
Evidence for the involvement of the glutathione pathway in drug resistance in AML: J.M. Sargent, et al.; Adv. Exp. Med. Biol. 457, 205 (1999), Abstract;
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol. 52, 450 (1999), Abstract;
Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998), Abstract;
Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival: A.G. Borg, et al.; Br. J. Haematol. 103, 1083 (1998), Abstract;
Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996), Abstract;
Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in human cancers: K. Nooter, et al.; Clin. Cancer Res. 1, 1301 (1995), Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract;
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994), Abstract;
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J. Zaman, et al.; PNAS 91, 8822 (1994), Abstract; Full Text

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