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MRP1 (human) monoclonal antibody (MRPm5)

 
ALX-801-012-C250 250 µg 777.00 USD
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Product Specification

Alternative Name:Multidrug resistance-associated protein 1, ABCC1
 
Clone:MRPm5
 
Host:Mouse
 
Isotype:IgG2
 
Immunogen:Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 986-1204).
 
UniProt ID:P33527
 
Species reactivity:Human
 
Specificity:Recognizes an internal epitope of human MRP1, overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP5.
 
Applications:Flow Cytometry, ICC, IHC (FS), WB
 
Recommended Dilutions/Conditions:Suggested starting dilution is 1:20
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
Immunohistochemistry: Suitable for frozen sections, weak in paraffin sections.
 
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier: J.S. Kumar, et al.; Sci. Rep. 6, 20418 (2016), Application(s): Western blot, Abstract;
Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion: J.D. Whitt, et al.; J. Biomed. Res. 30, 120 (2016), Application(s): Immunoblotting assays, Abstract; Full Text
Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region: C.J. Westlake, et al.; J. Biol. Chem. 279, 53571 (2004), Abstract; Full Text
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text
Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996), Abstract;
Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996), Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract;
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994), Abstract;
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J.R. Zaman, et al.; PNAS 91, 8822 (1994), Abstract; Full Text
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line: S.P. Cole, et al.; Science 258, 1650 (1992), Abstract;

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