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MRP1 (human) monoclonal antibody (QCRL-3)

 
ALX-801-011-L001 1 ml 345.00 USD
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Product Specification

Alternative Name:Multidrug resistance-associated protein 1, ABCC1
 
Clone:QCRL-3
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Membranes prepared from the human small cell lung cancer cell line H69AR.
 
UniProt ID:P33527
 
Species reactivity:Human
 
Specificity:Recognizes a conformation-dependent internal epitope (aa 617-932) of human MRP1 (multidrug resistance-associated protein 1), overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, or mouse MRP gene products.
 
Applications:Flow Cytometry, ICC, IHC (PS), IP, FUNC
 
Application Notes:Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
Functional Application: inhibits LTC4 transport
Not recommended for Western blot.
 
Formulation:Liquid. 0.22µm-filtered antibody in PBS containing 0.7% BSA and 0.1% sodium azide.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1: J. Renes, et al.; Br. J. Pharmacol. 126, 681 (1999), Abstract;
Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein: D.R. Hipfner, et al.; J. Biol. Chem. 274, 15420 (1999), Abstract; Full Text
MRP expression in acute myeloid leukemia. An update: M. Filipits, et al.; Adv. Exp. Med. Biol. 457, 141 (1999), Abstract;
Structural, mechanistic and clinical aspects of MRP1: D.R. Hipfner, et al.; Biochim. Biophys. Acta 1461, 359 (1999), Abstract;
MRP and MDR1 gene expression in primary breast carcinomas: M. Filipits, et al.; Clin. Cancer Res. 2, 1231 (1996), Abstract;
Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport: D.W. Loe, et al.; J. Biol. Chem. 271, 9675 (1996), Abstract; Full Text
Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell: K.C. Almquist, et al.; Cancer Res. 55, 102 (1995), Abstract;
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res. 54, 5788 (1994), Abstract;

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