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MRP1 (human) monoclonal antibody (QCRL-1)

 
ALX-801-010-L001 1 ml 528.00 USD
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Product Specification

Alternative Name:Multidrug resistance-associated protein 1, ABCC1
 
Clone:QCRL-1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Membranes prepared from the human small cell lung cancer cell line H69AR.
 
UniProt ID:P33527
 
Species reactivity:Human
 
Specificity:Recognizes the linear internal epitope (S918SYSGDI924) of human MRP1 (multidrug resistance-associated protein 1), overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP5, or mouse MRP gene products.
 
Applications:Flow Cytometry, ICC, IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Flow Cytometry (1:20)
Immunocytochemistry (1:20-1:50)
Western Blot (0.02-0.2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
 
Formulation:Liquid. 0.22μm-filtered solution in PBS containing 0.7% BSA and 0.1% sodium azide.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
801-010n
Figure: Human MRP1-specific MAb QCRL-1 (Prod.No. ALX-801-010).
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801-010n

Product Literature References

Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract;
The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract;
ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells: Q. Mao, et al.; Biochim. Biophys. Acta 1461, 69 (1999), Abstract;
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier: V.V. Rao, et al.; PNAS 96, 3900 (1999), Abstract; Full Text
Expression of the multidrug resistance protein (MRP1) in breast cancer: M. Filipits, et al.; Anticancer Res. 19, 5043 (1999), Abstract;
MRP expression in acute myeloid leukemia. An update: M. Filipits, et al.; Adv. Exp. Med. Biol. 457, 141 (1999), Abstract;
Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998), Abstract;
Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung: S.R. Wright, et al.; Clin. Cancer Res. 4, 2279 (1998), Abstract;
Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1: D.R. Hipfner, et al.; Cancer Res. 56, 3307 (1996), Abstract;
MRP and MDR1 gene expression in primary breast carcinomas: M. Filipits, et al.; Clin. Cancer Res. 2, 1231 (1996), Abstract;
Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell: K.C. Almquist, et al.; Cancer Res. 55, 102 (1995), Abstract;
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res. 54, 5788 (1994), Abstract;

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