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MRP1 monoclonal antibody (MRPr1)

 
ALX-801-007-C125 125 µg 453.00 USD
 
ALX-801-007-C250 250 µg 830.00 USD
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Product Specification

Alternative Name:Multidrug resistance-associated protein 1, ABCC1
 
Clone:MRPr1
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 192-360).
 
UniProt ID:P33527
 
Species reactivity:Human, Mouse
 
Specificity:Recognizes the internal epitope (G238SDLWSLNKE247) of MRP1, overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
 
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP 5.
 
Applications:Flow Cytometry, ICC, IHC (FS), IHC (PS), WB
 
Recommended Dilutions/Conditions:Suggested starting dilution is 1:20
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
 
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
801-013
Figure: Epitope Mapping of MAbs MRPr1, QCRL-1 & MRPm6. Topological model of MRPdepicting the approx. locations of the MRPr1, QCRL-1 and MRPm6 epitopes. The model shown is only one of several possible configurations. MSD=membrane spanning domain; NBD=nucleotide binding domain. From R. Hipfner, et al.; Br. J. Cancer 78,1134 (1998).
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801-013

Product Literature References

Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β: E. Roundhill, et al.; FASEB J. 30, 1712 (2016), Abstract;
Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier: A. Bernd, et al.; Pharm. Res. 32, 2973 (2015), Abstract;
Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen: L. Cheung, et al.; Biochem. Pharmacol. 93, 380 (2015), Application(s): Western blot with HEK293 cells, Abstract;
Inhibition of Multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme: A. Tivnan, et al.; Front. Neurosci. 9, 218 (2015), Application(s): Western Blot, Abstract; Full Text
The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: Implications in the individualized transplacental digoxin treatment for fetal heart failure: C. Wang, et al.; Placenta 36, 1138 (2015), Application(s): Western blot with human placenta, Abstract; Full Text
High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4): L. Cheung, et al.; Biochem. Pharmacol. 91, 97 (2014), Application(s): Western blot with MCF7 cells, Abstract;
Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function: L. Qin, et al.; Drug. Metab. Dispos. 40, 1403 (2012), Application(s): Immunofluorescence using HEK293 cells, Abstract;
Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia: C.J. Gibson, et al.; J. Pharmacol. Exp. Ther. 343, 650 (2012), Application(s): Western blot with BV-2 cells, Abstract; Full Text
Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region: C.J. Westlake, et al.; J. Biol. Chem. 279, 53571 (2004), Abstract; Full Text
Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract;
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text
The multidrug resistance protein 1: a functionally important activation marker for murine Th1 cells: S. Prechtl, et al.; J. Immunol. 164, 754 (2000), Abstract; Full Text
The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract;
Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines: V. Nuessler, et al.; Leukemia 13, 1864 (1999), Abstract;
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier: V.V. Rao, et al.; PNAS 96, 3900 (1999), Abstract; Full Text
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma: H.J. Arts, et al.; Clin. Cancer Res. 5, 2798 (1999), Abstract; Full Text
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol. 52, 450 (1999), Abstract;
Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts: M. Pallis, et al.; Adv. Exp. Med. Biol. 457, 77 (1999), Abstract;
Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998), Abstract;
Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia: M.L. Den Boer, et al.; Blood 91, 2092 (1998), Abstract; Full Text
Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997), Abstract;
The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer: K. Nooter, et al.; Br. J. Cancer 76, 486 (1997), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996), Abstract;
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations: W.T. Beck, et al.; Cancer Res. 56, 3010 (1996), Abstract;
Multidrug resistance-associated protein expression in clinical gastric carcinoma: K. Endo, et al.; Cancer 77, 1681 (1996), Abstract;
Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in human cancers: K. Nooter, et al.; Clin. Cancer Res. 1, 1301 (1995), Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract;
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res. 54, 5788 (1994), Abstract;
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994), Abstract;
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J. Zaman, et al.; PNAS 91, 8822 (1994), Abstract; Full Text

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