Mycotoxin found in cereals. Binds to the ribosome and inhibits protein synthesis.
Emetic and refusal activity in pig.
Product Details
| Alternative Name: | DON, 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin |
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| Formula: | C15H20O6 |
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| MW: | 296.3 |
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| Source: | Isolated from Fusarium sp. |
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| CAS: | 51481-10-8 |
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| MI: | 14: 10032 |
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| RTECS: | YD0167000 |
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| Purity: | ≥98% (TLC, HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in methanol or ethyl acetate; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2: A.K. Diesing, et al.; Toxicol. Lett.
200, 8 (2011),
Abstract;
Ribotoxic mycotoxin deoxynivalenol induces G(2)/M cell cycle arrest via p21(Cip/WAF1) mRNA stabilization in human epithelial cells: H. Yang, et al.; Toxicology
243, 145 (2008),
Abstract;
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture: M. Königs, et al.; Toxicology
240, 48 (2007),
Abstract;
Some major mycotoxins and their mycotoxicoses--an overview: J.L. Richard; Int. J. Food Microbiol.
119, 3 (2007), (Review),
Abstract;
The effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan adsorbent on lactation, serum chemistry, and reproductive performance after weaning of first-parity lactating sows: G. Diaz-Llano & T.K. Smith; J. Anim. Sci.
85, 1412 (2007),
Abstract;
Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum: N. Ponts, et al.; FEMS Microbiol. Lett.
258, 102 (2006),
Abstract;
Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations: T. Sergent, et al.; Toxicol. Lett.
164, 167 (2006),
Abstract;
Detection of deoxynivalenol in foods and indoor air using an array biosensor: M.M. Ngundi, et al.; Environ. Sci. Technol.
40, 2352 (2006),
Abstract;
Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages: Q. Jia, et al.; J. Nutr.
136, 366 (2006),
Abstract;
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Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes: T. Goyarts, et al.; Toxicol. In Vitro
20, 858 (2006),
Abstract;
Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens: W.A. Awad, et al.; J. Anim. Physiol. Anim. Nutr. (Berl)
90, 32 (2006),
Abstract;
Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants: J. Pestka & H.R. Zhou; Toxicol. Sci.
92, 445 (2006),
Abstract;
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Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice: M.E. Gouze, et al.; Cell. Mol. Biol. (Noisy-le-grand)
51, OL809 (2005),
Abstract;
The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for Fusarium head blight resistance in wheat: M. Lemmens, et al.; Mol. Plant Microbe Interact.
18, 1318 (2005),
Abstract;
Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs: H. Kamimura, et al.; J. Assoc. Off. Anal. Chem.
64, 1067 (1981),
Abstract;
Emetic and refusal activity of deoxynivalenol to swine: D.M. Forsyth, et al.; Appl. Environ. Microbiol.
34, 547 (1977),
Abstract;
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