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ALX-630-115-M001 1 mg 77.00 USD
ALX-630-115-M005 5 mg 320.00 USD
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Mycotoxin found in cereals. Binds to the ribosome and inhibits protein synthesis.
Emetic and refusal activity in pig.

Product Specification

Alternative Name:DON, 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin
Source:Isolated from Fusarium sp.
MI:14: 10032
Purity:≥98% (TLC, HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in methanol or ethyl acetate; slightly soluble in water.
Long Term Storage:+4°C
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Product Literature References

Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2: A.K. Diesing, et al.; Toxicol. Lett. 200, 8 (2011), Abstract;
Ribotoxic mycotoxin deoxynivalenol induces G(2)/M cell cycle arrest via p21(Cip/WAF1) mRNA stabilization in human epithelial cells: H. Yang, et al.; Toxicology 243, 145 (2008), Abstract;
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture: M. Königs, et al.; Toxicology 240, 48 (2007), Abstract;
Some major mycotoxins and their mycotoxicoses--an overview: J.L. Richard; Int. J. Food Microbiol. 119, 3 (2007), (Review), Abstract;
The effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan adsorbent on lactation, serum chemistry, and reproductive performance after weaning of first-parity lactating sows: G. Diaz-Llano & T.K. Smith; J. Anim. Sci. 85, 1412 (2007), Abstract;
Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum: N. Ponts, et al.; FEMS Microbiol. Lett. 258, 102 (2006), Abstract;
Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations: T. Sergent, et al.; Toxicol. Lett. 164, 167 (2006), Abstract;
Detection of deoxynivalenol in foods and indoor air using an array biosensor: M.M. Ngundi, et al.; Environ. Sci. Technol. 40, 2352 (2006), Abstract;
Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages: Q. Jia, et al.; J. Nutr. 136, 366 (2006), Abstract; Full Text
Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes: T. Goyarts, et al.; Toxicol. In Vitro 20, 858 (2006), Abstract;
Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens: W.A. Awad, et al.; J. Anim. Physiol. Anim. Nutr. (Berl) 90, 32 (2006), Abstract;
Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants: J. Pestka & H.R. Zhou; Toxicol. Sci. 92, 445 (2006), Abstract; Full Text
Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice: M.E. Gouze, et al.; Cell. Mol. Biol. (Noisy-le-grand) 51, OL809 (2005), Abstract;
The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for Fusarium head blight resistance in wheat: M. Lemmens, et al.; Mol. Plant Microbe Interact. 18, 1318 (2005), Abstract;
Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs: H. Kamimura, et al.; J. Assoc. Off. Anal. Chem. 64, 1067 (1981), Abstract;
Emetic and refusal activity of deoxynivalenol to swine: D.M. Forsyth, et al.; Appl. Environ. Microbiol. 34, 547 (1977), Abstract; Full Text

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