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NSTX-3

Glutamate inhibitor
 
ALX-630-087-C100 100 µg 86.00 USD
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Originally isolated from Nephila maculata. Specific, irreversible spider neurotoxin, that inhibits both glutamate and postsynaptic potentials in the neuromuscular junction. Specifically blocks Na+-channels.

Product Specification

Alternative Name:2,4-Dihydroxyphenylacetyl-L-asparaginyl-N'-(L-arginyl-puteanyl)-cadaverine
 
Formula:C30H52N10O7
 
MW:664.8
 
Source:Synthetic.
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 0.1% acetic acid solution.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:We do not recommend storing aqueous solutions for more than a few weeks.
 
Handling:Protect from light. After reconstitution, prepare aliquots and store at -20°C.
 
ALX-630-087
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ALX-630-087

Product Literature References

Novel mechanism of blocking axonal Na(+) channels by three macrocyclic polyamine analogues and two spider toxins: M. Yakehiro, et al.; Br. J. Pharmacol. 132, 63 (2001), Abstract;
Total synthesis of nstx-3, spider toxin of nephila maculata : T. Teshima, et al.; Tetrahedron 47, 3305 (1991),
Characterization of binding sites for spider toxin, [3H]NSTX-3, in the rat brain: H. Ino, et al.; Neurosci. Res. 8, 29 (1990), Abstract;
Synthesis of a new neurotoxin NSTX-3 of Papua New Guinean spider: T. Teshima, et al.; THL 28, 3509 (1987),
Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain: Y. Aramaki, et al.; Proc. Jpn. Acad. 62B, 359 (1986),

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