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Podophyllotoxin

Topoisomerase inhibitor
 
ALX-630-086-M100 100 mg 40.00 USD
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Potent inhibitor of microtubule assembly. Antineoplastic glucoside. Antitumor agent. DNA topoisomerase II inhibitor.

Product Specification

Formula:C22H22O8
 
MW:414.4
 
Source:Isolated from Podophyllum peltatum.
 
CAS:518-28-5
 
MI:14: 7546
 
RTECS:LV2500000
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and LC-MS.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in chloroform, 100 % ethanol, acetone or dichloromethane; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Very hygroscopic. Protect from moisture. Keep under inert gas.
 
ALX-630-086
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ALX-630-086

Product Literature References

An evidence-based review of medical and surgical treatments of genital warts.: N. Scheinfeld & DS. Lehman; Dermatol. Online J. 12, 5 (2006), Abstract;
Er:YAG laser followed by topical podophyllotoxin for hard-to-treat palmoplantar warts.: U. Wollina; Cosmet. Laser Ther. 5, 35 (2003), Abstract;
Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994), Abstract;
Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin: D.L. Sackett; Pharmacol. Therap. 59, 163 (1993), Abstract;
Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharm. Bull. (Tokyo) 40, 2720 (1992), Abstract;
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross- resistance studies with various microtubule inhibitors and podophyllotoxin analogues: R.S. Gupta; Cancer Res. 43, 505 (1983), Abstract;

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