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Kaliotoxin

Ca2+-activated K+ channel blocker
 
ALX-630-085-C010 10 µg 138.00 USD
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High conductance Ca2+-activated K+ channel blocker. Highly selective for Kv1.1 and Kv1.3. Blocking of Kv1.3 inhibits T cell activation.

Product Specification

Alternative Name:KTx
 
Sequence:H-Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys-OH
(Disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35)
 
Formula:C171H283N55O49S8
 
MW:4150.0
 
Source:Synthetic. Originally isolated from Androctonus mauretanicus mauretanicus scorpion venom.
 
CAS:145199-73-1
 
Purity:≥98%
 
Appearance:Lyophilized.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR: A. Lange, et al.; Nature 440, 959 (2006), Abstract;
Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease: P. Valverde, et al.; J. Bone Miner. Res. 19, 955 (2004), Abstract;
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation: C. Beeton, et al.; J. Immunol. 166, 936 (2001), Abstract;
Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits: C. Mourre, et al.; J. Pharmacol. Exp. Ther. 291, 943 (1999), Abstract;
3D structure of kaliotoxin: is residue 34 a key for channel selectivity?: M. Gairi, et al.; J. Pept. Sci. 3, 314 (1997), Abstract;
Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?: R. Romi, et al.; J. Biol. Chem. 268, 26302 (1993), Abstract; Full Text
Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)- activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom: M. Crest, et al.; J. Biol. Chem. 267, 1640 (1992), Abstract; Full Text

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