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United States 

Ryanodine (high purity)

Ca2+ channel activator
ALX-630-062-M001 1 mg 154.00 USD
ALX-630-062-M005 5 mg 583.00 USD
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Replaces Prod. #: BML-CA450

Induces the release of intracellular Ca2+ . Ryanodine receptors mediate adenine nucleotide, Ca2+ and caffeine-sensitive release of Ca2+ from sarcoplasmic reticulum of cardiac and skeletal muscle and may also mediate intracellular Ca2+ release in neurons. Biphasic effect on sarcoplasmic reticulum calcium channels; Nanomolar levels open the channel and micromolar levels close it.

Product Specification

Source:Isolated from Ryania speciosa, Flacourtiaceae.
MI:14: 8307
Purity:≥99% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in methanol or DMSO (>29mg/ml), in 100% ethanol (16mg/ml); slightly soluble in water (warm).
Long Term Storage:-20°C
Handling:Protect from light.
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Product Literature References

Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation: W. Xin, et al.; Am. J. Physiol. Cell Physiol. 303, C1079 (2012), Application(s): ELISA analysis of guinea pig and human DSM cells, Abstract; Full Text
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation: T. Adasme, et al.; PNAS U.S.A. 108, 3029 (2011), Abstract; Full Text
The interaction of ryanoids with individual ryanodine receptor channels: A. J. Williams and B. Tanna; Biol. Res. 37, 527 (2004), Abstract;
The pharmacology of ryanodine and related compounds: J. L. Sutko, et al.; Pharmacol. Rev. 49, 53 (1997), Abstract;
Cyclic ADP-ribose: a new way to control calcium: A. Galione; Science 259, 325 (1993), Abstract;
The ryanodine receptor/Ca2+ release channel: P.S. McPherson & K.P. Campbell; J. Biol. Chem. 268, 13765 (1993), Abstract;
Ryanodine as a functional probe of the skeletal muscle sarcoplasmic reticulum Ca2+ release channel: G. Meissner & A. el-Hashem; Mol. Cell. Biochem. 114, 119 (1992), Abstract;
The brain ryanodine receptor: a caffeine-sensitive calcium release channel: P.S. McPherson et al.; Neuron 7, 17 (1991), Abstract;
Depolarization promotes caffeine induced [3H]-noradrenaline release in calcium-free solution from peripheral sympathetic nerves: P.T. Toth et al.; Cell. Calcium 11, 557 (1990), Abstract;
Rapid kinetic analysis of the calcium-release channels of skeletal muscle sarcoplasmic reticulum: the effect of inhibitors: G. Calviello & M. Chiesi ; Biochemistry 28, 1301 (1989), Abstract;
Structural aspects of ryanodine action and selectivity: A.L. Waterhouse, et al.; J. Med. Chem. 30, 710 (1987), Abstract;
Mechanism of action of ryanodine on cardiac sarcoplasmic reticulum: J.J. Feher & G.B. Lipford; Biochim. Biophys. Acta 813, 77 (1985), Abstract;
Rapid flow chemical quench studies of calcium release from isolated sarcoplasmic reticulum: N. Ikemoto et al.; J. Biol. Chem. 260, 14096 (1985), Abstract;
Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle: J.L. Sutko, et al.; Fed. Prod. 44, 2984 (1985), Abstract;
The calcium-ryanodine receptor complex of skeletal and cardiac muscle: I.N. Pessah, et al.; BBRC 128, 449 (1985), Abstract;
Ryanodine modification of cardiac muscle responses to potassium-free solutions. Evidence for inhibition of sarcoplasmic reticulum calcium release: J.L. Sutko & J.L. Kenyon; J. Gen. Physiol. 82, 385 (1983), Abstract;
The pharmacology of ryanodine: D.J. Jenden & A.S. Fairhurst; Pharmacol. Rev. 21, 1 (1969), (Review), Abstract;

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