β-Bungarotoxin

Neurotoxin



ALX-630-050-M001	1 mg	59.00 USD

Presynaptic, neurotoxic phospholipase A₂ activity.

Product Specification

Alternative Name:	β-BuTx

MW:	6979.0

Purity:	≥98%

Appearance:	Lyophilized.

CAS:	12778-32-4

MI:	14: 1488

Source/Host:	Isolated from Bungarus multicinctus.

Solubility:	Soluble in water or aqueous buffers.

Long Term Storage:	-20°C

Hazard:	HARMFUL.

Product Literature References

Mechanism of beta-bungarotoxin in facilitating spontaneous transmitter release at neuromuscular synapse: J.C. Liou, et al.; Neuropharmacology 51, 671 (2006), Abstract;

Phospholipase A(2) activity of beta-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons: Y.J. Chen; J. Neurobiol. 64, 213 (2005), Abstract;

Induction by beta-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca(2+)-dependent formation of reactive oxygen species: O. Shakhman, et al.; J. Neurochem. 87, 598 (2003), Abstract;

What does beta-bungarotoxin do at the neuromuscular junction?: E.G. Rowan; Toxicon 39, 107 (2001), (Review), Abstract;

Mechanism of action of beta-bungarotoxin, a presynaptically acting phospholipase A2 neurotoxin: its effect on protein phosphorylation in rat brain synaptosomes: E. Ueno & P. Rosenberg; Toxicon 34, 1219 (1996), Abstract;

Nucleotide sequence encoding beta-bungarotoxin A2-chain from the venom glands of Bungarus multicinctus: J.M. Danse, et al.; Nucl. Acids Res. 18, 4609 (1990), Abstract;

Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), (Review), Abstract;

Cross-linking of beta-bungarotoxin to chick brain membranes. Identification of subunits of a putative voltage-gated K+ channel: R.R. Schmidt & H. Betz; Biochemistry 28, 8346 (1989), Abstract;

Beta-bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones: M. Petersen, et al.; Neurosci. Lett. 68, 141 (1986), Abstract;

Solubilization and characterization of the beta-bungarotoxin-binding protein of chick brain membranes: H. Rehm & H. Betz; J. Biol. Chem. 259, 6865 (1984), Abstract; Full Text

Amino acid sequence of beta 2-bungarotoxin from Bungarus multicinctus venom. The amino acid substitutions in the B chains: K. Kondo, et al.; J. Biochem. 91, 1519 (1982), Abstract;

Amino acid sequences of three beta-bungarotoxins (beta 3-, beta 4-, and beta 5- bungarotoxins) from Bungarus multicinctus venom. Amino acid substitutions in the A chains: K. Kondo; J. Biochem. 91, 1531 (1982), Abstract;

Biochemical and electrophysiological demonstrations of the actions of beta-bungarotoxin on synapses in brain: J.V. Halliwell; J. Neurochem. 39, 543 (1982), Abstract;

Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald; Neuroscience 6, 1 (1981), Abstract;

Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al; BBRC 44, 711 (1971), Abstract;

Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970), Abstract;