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α-Conotoxin SI

 
ALX-630-049-C500 500 µg 560.00 USD
 
Neurotoxin. Postsynaptic inhibitor at the neuromuscular junction. Selective antagonist of neuromuscular or neuronal nicotinic acetylcholine receptors. Not for sale in U.S.A.

Product Specification

Formula:C55H83N16O16S4
 
MW:1352.6
 
Purity:≥96%
 
Appearance:Lyophilized.
 
Sequence:H-Ile-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Pro-Lys-Tyr-Ser-Cys-NH2
(Disulfide bonds between Cys2-Cys7and Cys3-Cys13)
 
Source/Host:Synthetic. Originally isolated from Conus striatus.
 
Solubility:Soluble in water.
 
Shipping:AMBIENT
 
Long Term Storage:-20°C
 
Hazard:VERY TOXIC.
 

Product Literature References

Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI: G.C. Zafaralla, et al.; Biochemistry 27, 7102 (1988), Abstract;
Synthesis of .alpha.-conotoxin SI, a bicyclic tridecapeptide amide with two disulfide bridges: illustration of novel protection schemes and oxidation strategies: M.C. Munson & G. Barany; JACS 115, 10203 (1993),
The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not: R.M. Hann, et al.; Biochemistry 33, 14058 (1994), Abstract;
alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads: J. L. Dutton & D. J. Craik; Curr. Med. Chem. 8, 327 (2001), (Review), Abstract;
Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes: A. Nicke, et al.; Eur. J. Biochem. 271, 2305 (2004), (Review), Abstract;
alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses: R.W. Janes; Curr. Opin. Pharmacol. 5, 280 (2005), (Review), Abstract;

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