α-Conotoxin SI



ALX-630-049-C500	500 µg	560.00 USD

Neurotoxin. Postsynaptic inhibitor at the neuromuscular junction. Selective antagonist of neuromuscular or neuronal nicotinic acetylcholine receptors. Not for sale in U.S.A.

Product Specification

Formula:	C₅₅H₈₃N₁₆O₁₆S₄

MW:	1352.6

Purity:	≥96%

Appearance:	Lyophilized.

Sequence:	H-Ile-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Pro-Lys-Tyr-Ser-Cys-NH₂ (Disulfide bonds between Cys²-Cys⁷and Cys³-Cys¹³)

Source/Host:	Synthetic. Originally isolated from Conus striatus.

Solubility:	Soluble in water.

Shipping:	AMBIENT

Long Term Storage:	-20°C

Hazard:	VERY TOXIC.

Product Literature References

Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI: G.C. Zafaralla, et al.; Biochemistry 27, 7102 (1988), Abstract;

Synthesis of .alpha.-conotoxin SI, a bicyclic tridecapeptide amide with two disulfide bridges: illustration of novel protection schemes and oxidation strategies: M.C. Munson & G. Barany; JACS 115, 10203 (1993),

The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not: R.M. Hann, et al.; Biochemistry 33, 14058 (1994), Abstract;

alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads: J. L. Dutton & D. J. Craik; Curr. Med. Chem. 8, 327 (2001), (Review), Abstract;

Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes: A. Nicke, et al.; Eur. J. Biochem. 271, 2305 (2004), (Review), Abstract;

alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses: R.W. Janes; Curr. Opin. Pharmacol. 5, 280 (2005), (Review), Abstract;