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Cysteine protease inhibitor
 
ALX-620-080-M002 2 mg 736.00 USD
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Irreversible, cell permeable, biotin-labelled inhibitor of cysteine proteases.

Product Specification

Alternative Name:Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate
 
Formula:C34H42N4O7S
 
MW:650.8
 
CAS:744207-03-2
 
Purity:≥98% (HPLC)
 
Appearance:White to yellow solid.
 
Solubility:Soluble in DMSO (50mg/ml), 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
620-080
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620-080

Product Literature References

Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles: U. Schurigt, et al.; Antimicrob. Agents Chemother. 54, 5028 (2010), Abstract;
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells: C. Gelhaus, et al.; Biol. Chem. 386, 499 (2005), Abstract;
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate: C. Gelhaus, et al.; Biol. Chem. 385, 435 (2004), Abstract;

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