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Lucigenin

ROS dye
 
ALX-620-061-M050 50 mg 37.00 USD
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Chemiluminescent probe for the detection of superoxide in biological systems.

Product Specification

Alternative Name:bis-N-Methylacridinium nitrate, N,N'-Dimethyl-9,9'-biacridinium dinitrate
 
Formula:C28H22N4O6
 
MW:510.5
 
CAS:2315-97-1
 
Purity:≥97% (HPLC)
 
Appearance:Off-white to brown powder.
 
Solubility:Soluble in DMSO (~12mg/ml), 100% ethanol (~0.5mg/ml) or acetic acid (~10mg/ml, heat up solution).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
ALX-620-061
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ALX-620-061

Product Literature References

PKC/NADPH oxidase are involved in the protective effect of pioglitazone in high homocysteine-induced paracrine dyfunction in endothelial progenitor cells: S. Xu, et al.; Am. J. Transl. Res. 9, 1037 (2017), Abstract; Full Text
Globular adiponectin attenuates LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling: A. Shrestha & P.H. Park; Life Sci. 148, 71 (2016), Application(s): Cell culture, Abstract;
Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1- MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin- Stimulated Endothelial Cells: K. Ando, et al.; J. Atheroscler. Thromb. 18, 762 (2011), Abstract; Full Text
In retinal vein occlusion platelet response to thrombin is increased: G. Leoncini, et al.; Thromb Res. 124, e48 (2009), Abstract;
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res. 84, 1203 (1999), Abstract;
Lucigenin as a substrate of microsomal NAD(P)H-oxidoreductases: I.A. Schepetkin; Biochemistry (Mosc.) 64, 25 (1999), Abstract;
Lucigenin is a mediator of cytochrome C reduction but not of superoxide production: I.B. Afanas'ev, et al.; Arch. Biochem. Biophys. 366, 267 (1999), Abstract;
Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production: M.P. Skatchkov, et al.; BBRC 254, 319 (1999), Abstract;
Lucigenin as mediator of superoxide production: revisited: S.I. Liochev & I. Fridovich; Free Radic. Biol. Med. 25, 926 (1998), Abstract;
Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems: Y. Li, et al.; J. Biol. Chem. 273, 2015 (1998), Abstract; Full Text
What do we measure with luminol-, lucigenin- and penicillin-amplified chemiluminescence? 1. Investigations with hydrogen peroxide and sodium hypochlorite: M. Rost, et al.; J. Biolumin. Chemilumin. 13, 355 (1998), Abstract;

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