Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Zinquin ethyl ester

Zinc dye
 
ALX-620-044-M001 1 mg 89.00 USD
Do you need bulk/larger quantities?
 
Fluorescent, membrane permeable probe of zinc ions which can be used to measure or visualize intracellular zinc. Used to demonstrate changes in zinc flux in cells undergoing early events of apoptosis.

Product Specification

Alternative Name:(2-Methyl-8-(4-methylphenylsulfonylamino)quinolinyl)oxyacetic acid ethyl ester
 
Formula:C21H22N2O5S
 
MW:414.5
 
CAS:181530-09-6
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in 100% ethanol, methanol or DMSO; slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Scientific Background:Zinc (Zn) is the second most abundant transition metal in the body ant it is essential as catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and aging. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases including Alzheimer’s disease, Parkinson’s disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluroescent imaging.
 
620-044
Please mouse over
620-044

Product Literature References

Inhibition of MMP-13 with modified polymer particles: H. Tran, et al.; Surf. Sci. (2015), Application(s): Cell culture,
Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes: I.A. Brand & J. Kleineke; J. Biol. Chem. 271, 1941 (1996), Abstract; Full Text
Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin: P.D. Zalewski, et al.; Chem. Biol. 1, 153 (1994), Abstract;
Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc: P. Coyle, et al.; Biochem. J. 303, 781 (1994), Abstract;
Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc: P.D. Zalewski, et al.; J. Histochem. Cytochem. 42, 877 (1994), Abstract;
Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II): P.D. Zalewski, et al.; Biochem. J. 296, 403 (1993), Abstract;

General Literature References

Mechanism and regulation of cellular zinc transport: I. Sekler, et al.; Mol. Med. 13, 337 (2007), Abstract; Full Text
Sticky fingers: zinc-fingers as protein-recognition motifs: R. Gamsjaeger, et al.; TIBS 32, 63 (2007), Abstract;
Zinc: a multipurpose trace element: M. Stefanidou, et al.; Arch. Toxicol. 80, 1 (2006), Abstract;
Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors: P. Jiang & Z. Guo; Coord. Chem. Rev. 248, 205 (2004),
Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death: A.Q. Truong-Tran, et al.; J. Nutr. 130, 1459S (2000), Abstract; Full Text

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Zinc
By biological activity:
Zinc Dye
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Monitor programmed cell death from membrane to nucleus
Monitor programmed cell death from membrane to nucleus
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,